diff --git a/pkgs/development/python-modules/pylti/default.nix b/pkgs/development/python-modules/pylti/default.nix
deleted file mode 100644
index a4f4abcb7304243..000000000000000
--- a/pkgs/development/python-modules/pylti/default.nix
+++ /dev/null
@@ -1,53 +0,0 @@
-{ lib
-, buildPythonPackage
-, fetchPypi
-, httplib2
-, oauth
-, oauth2
-, semantic-version
-, flask
-, httpretty
-, oauthlib
-, pyflakes
-, pytest
-, pytestcache
-, pytest-cov
-, cov-core
-, pytest-flakes
-, sphinx
-, mock
-, chalice
-, isPy27
-}:
-
-buildPythonPackage rec {
-  pname = "pylti";
-  version = "0.7.0";
-  format = "setuptools";
-
-  disabled = !isPy27;
-
-  # There is no need to fix mock. https://github.com/mitodl/pylti/pull/48
-  postPatch = ''
-    substituteInPlace setup.py --replace "mock==1.0.1" "mock"
-  '';
-
-  propagatedBuildInputs = [ httplib2 oauth oauth2 semantic-version ];
-  nativeCheckInputs = [
-    flask httpretty oauthlib pyflakes pytest pytestcache pytest-cov cov-core
-    pytest-flakes sphinx mock chalice
-  ];
-
-  src = fetchPypi {
-    pname = "PyLTI";
-    inherit version;
-    sha256 = "80938a235b1ab390f6889a95237d087ea7adde5cc50fcae9c80c49898e8ee78e";
-  };
-
-  meta = {
-    description = "Implementation of IMS LTI interface that works with edX";
-    homepage = "https://github.com/mitodl/pylti";
-    license = lib.licenses.bsdOriginal;
-    maintainers = with lib.maintainers; [ layus ];
-  };
-}
diff --git a/pkgs/top-level/python-aliases.nix b/pkgs/top-level/python-aliases.nix
index 1cb4524df595021..caf1e8fbc970b38 100644
--- a/pkgs/top-level/python-aliases.nix
+++ b/pkgs/top-level/python-aliases.nix
@@ -364,6 +364,7 @@ mapAliases ({
   pyhs100 = throw "pyhs100 has been removed in favor of python-kasa."; # added 2024-01-05
   pylibgen = throw "pylibgen is unmaintained upstreamed, and removed from nixpkgs"; # added 2020-06-20
   PyLD = pyld; # added 2022-06-22
+  pylti = throw "pylti has been removed because it is unmaintained since 2019"; # added 2024-05-21
   pymaging = throw "pymaging has been removed because it has not been maintained for 10 years and has been archived."; # added 2023-11-04
   pymaging_png = throw "pymaging_png has been removed because it has not been maintained for 10 years and has been archived."; # added 2023-11-04
   pymatgen-lammps = throw "pymatgen-lammps has been removed because it is unmaintained and broken"; # added 2023-06-20
diff --git a/pkgs/top-level/python-packages.nix b/pkgs/top-level/python-packages.nix
index c86ac120b798c8f..5875eba20ce9bfb 100644
--- a/pkgs/top-level/python-packages.nix
+++ b/pkgs/top-level/python-packages.nix
@@ -11291,8 +11291,6 @@ self: super: with self; {
 
   pylpsd = callPackage ../development/python-modules/pylpsd { };
 
-  pylti = callPackage ../development/python-modules/pylti { };
-
   pylutron = callPackage ../development/python-modules/pylutron { };
 
   pylutron-caseta = callPackage ../development/python-modules/pylutron-caseta { };