diff --git a/kombu/__init__.py b/kombu/__init__.py
index e555262ec..a01ed151e 100644
--- a/kombu/__init__.py
+++ b/kombu/__init__.py
@@ -3,10 +3,6 @@
 import os
 import re
 import sys
-
-if sys.version_info < (2, 7):  # pragma: no cover
-    raise Exception('Kombu 4.6 requires Python versions 2.7 or later.')
-
 from collections import namedtuple  # noqa
 
 __version__ = '5.0.2'
diff --git a/kombu/serialization.py b/kombu/serialization.py
index b35cc2b86..1b9a0a6a7 100644
--- a/kombu/serialization.py
+++ b/kombu/serialization.py
@@ -330,13 +330,8 @@ def not_available(*args, **kwargs):
         registry.register('yaml', None, not_available, 'application/x-yaml')
 
 
-if sys.version_info[0] == 3:  # pragma: no cover
-
-    def unpickle(s):
-        return pickle_loads(str_to_bytes(s))
-
-else:
-    unpickle = pickle_loads  # noqa
+def unpickle(s):
+    return pickle_loads(str_to_bytes(s))
 
 
 def register_pickle():
diff --git a/kombu/transport/virtual/base.py b/kombu/transport/virtual/base.py
index 1f1b563e5..669c6f0fb 100644
--- a/kombu/transport/virtual/base.py
+++ b/kombu/transport/virtual/base.py
@@ -28,7 +28,7 @@
 
 from .exchange import STANDARD_EXCHANGE_TYPES
 
-ARRAY_TYPE_H = 'H' if sys.version_info[0] == 3 else b'H'
+ARRAY_TYPE_H = 'H'
 
 UNDELIVERABLE_FMT = """\
 Message could not be delivered: No queues bound to exchange {exchange!r} \
diff --git a/kombu/utils/functional.py b/kombu/utils/functional.py
index ccc916126..02ed6ffa7 100644
--- a/kombu/utils/functional.py
+++ b/kombu/utils/functional.py
@@ -3,7 +3,6 @@
 from collections import OrderedDict, UserDict
 from collections.abc import Iterable, Mapping
 import random
-import sys
 import threading
 import inspect
 
@@ -126,20 +125,9 @@ def __setstate__(self, state):
         self.__dict__ = state
         self.mutex = threading.RLock()
 
-    if sys.version_info[0] == 3:  # pragma: no cover
-        keys = _iterate_keys
-        values = _iterate_values
-        items = _iterate_items
-    else:  # noqa
-
-        def keys(self):
-            return list(self._iterate_keys())
-
-        def values(self):
-            return list(self._iterate_values())
-
-        def items(self):
-            return list(self._iterate_items())
+    keys = _iterate_keys
+    values = _iterate_values
+    items = _iterate_items
 
 
 def memoize(maxsize=None, keyfun=None, Cache=LRUCache):
diff --git a/t/unit/test_serialization.py b/t/unit/test_serialization.py
index 01cb20f1e..82aec807c 100644
--- a/t/unit/test_serialization.py
+++ b/t/unit/test_serialization.py
@@ -1,7 +1,6 @@
 #!/usr/bin/python
 
 import pytest
-import sys
 
 from base64 import b64decode
 
@@ -202,12 +201,6 @@ def test_msgpack_loads(self):
         res = loads(msgpack_data,
                     content_type='application/x-msgpack',
                     content_encoding='binary')
-        if sys.version_info[0] < 3:
-            for k, v in res.items():
-                if isinstance(v, str):
-                    res[k] = v.encode()
-                if isinstance(v, (list, tuple)):
-                    res[k] = [i.encode() for i in v]
         assert res == msgpack_py_data
 
     @t.skip.if_pypy