diff --git a/src/coreclr/jit/lsrabuild.cpp b/src/coreclr/jit/lsrabuild.cpp
index 89fd0433e346b..5e0473ca906a4 100644
--- a/src/coreclr/jit/lsrabuild.cpp
+++ b/src/coreclr/jit/lsrabuild.cpp
@@ -619,16 +619,6 @@ RefPosition* LinearScan::newRefPosition(Interval*        theInterval,
     // Spill info
     newRP->isFixedRegRef = isFixedRegister;
 
-#ifndef TARGET_AMD64
-    // We don't need this for AMD because the PInvoke method epilog code is explicit
-    // at register allocation time.
-    if (theInterval != nullptr && theInterval->isLocalVar && compiler->compMethodRequiresPInvokeFrame() &&
-        theInterval->varNum == compiler->genReturnLocal)
-    {
-        mask &= ~(RBM_PINVOKE_TCB | RBM_PINVOKE_FRAME).GetRegSetForType(theInterval->registerType);
-        noway_assert(mask != RBM_NONE);
-    }
-#endif // !TARGET_AMD64
     newRP->registerAssignment = mask;
 
     newRP->setMultiRegIdx(multiRegIdx);
diff --git a/src/coreclr/jit/targetamd64.h b/src/coreclr/jit/targetamd64.h
index 1575177643eb1..f9c4e9369422a 100644
--- a/src/coreclr/jit/targetamd64.h
+++ b/src/coreclr/jit/targetamd64.h
@@ -383,14 +383,6 @@
   #define REG_SECRET_STUB_PARAM    REG_R10
   #define RBM_SECRET_STUB_PARAM    RBM_R10
 
-  // Registers used by PInvoke frame setup
-  #define REG_PINVOKE_FRAME        REG_EDI
-  #define RBM_PINVOKE_FRAME        RBM_EDI
-  #define REG_PINVOKE_TCB          REG_EAX
-  #define RBM_PINVOKE_TCB          RBM_EAX
-  #define REG_PINVOKE_SCRATCH      REG_EAX
-  #define RBM_PINVOKE_SCRATCH      RBM_EAX
-
   // The following defines are useful for iterating a regNumber
   #define REG_FIRST                REG_EAX
   #define REG_INT_FIRST            REG_EAX
diff --git a/src/coreclr/jit/targetarm64.h b/src/coreclr/jit/targetarm64.h
index 366a8e80fe08f..24448466d4715 100644
--- a/src/coreclr/jit/targetarm64.h
+++ b/src/coreclr/jit/targetarm64.h
@@ -224,14 +224,6 @@
   // JMP Indirect call register
   #define REG_INDIRECT_CALL_TARGET_REG    REG_IP0
 
-  // Registers used by PInvoke frame setup
-  #define REG_PINVOKE_FRAME        REG_R9
-  #define RBM_PINVOKE_FRAME        RBM_R9
-  #define REG_PINVOKE_TCB          REG_R10
-  #define RBM_PINVOKE_TCB          RBM_R10
-  #define REG_PINVOKE_SCRATCH      REG_R10
-  #define RBM_PINVOKE_SCRATCH      RBM_R10
-
   // The following defines are useful for iterating a regNumber
   #define REG_FIRST                REG_R0
   #define REG_INT_FIRST            REG_R0
diff --git a/src/coreclr/jit/targetloongarch64.h b/src/coreclr/jit/targetloongarch64.h
index dcc87944beb16..8a5fc86951bec 100644
--- a/src/coreclr/jit/targetloongarch64.h
+++ b/src/coreclr/jit/targetloongarch64.h
@@ -194,14 +194,6 @@
 
   #define REG_INDIRECT_CALL_TARGET_REG    REG_T6
 
-  // Registers used by PInvoke frame setup
-  #define REG_PINVOKE_FRAME        REG_T0
-  #define RBM_PINVOKE_FRAME        RBM_T0
-  #define REG_PINVOKE_TCB          REG_T1
-  #define RBM_PINVOKE_TCB          RBM_T1
-  #define REG_PINVOKE_SCRATCH      REG_T1
-  #define RBM_PINVOKE_SCRATCH      RBM_T1
-
   // The following defines are useful for iterating a regNumber
   #define REG_FIRST                REG_R0
   #define REG_INT_FIRST            REG_R0
diff --git a/src/coreclr/jit/targetriscv64.h b/src/coreclr/jit/targetriscv64.h
index a0d5254dc5d17..0fd6e1410016c 100644
--- a/src/coreclr/jit/targetriscv64.h
+++ b/src/coreclr/jit/targetriscv64.h
@@ -173,14 +173,6 @@
   // JMP Indirect call register
   #define REG_INDIRECT_CALL_TARGET_REG    REG_T5
 
-  // Registers used by PInvoke frame setup
-  #define REG_PINVOKE_FRAME        REG_T0
-  #define RBM_PINVOKE_FRAME        RBM_T0
-  #define REG_PINVOKE_TCB          REG_T1
-  #define RBM_PINVOKE_TCB          RBM_T1
-  #define REG_PINVOKE_SCRATCH      REG_T1
-  #define RBM_PINVOKE_SCRATCH      RBM_T1
-
   // The following defines are useful for iterating a regNumber
   #define REG_FIRST                REG_R0
   #define REG_INT_FIRST            REG_R0