diff --git a/.changeset/tame-lizards-kiss.md b/.changeset/tame-lizards-kiss.md
new file mode 100644
index 00000000..27c821f1
--- /dev/null
+++ b/.changeset/tame-lizards-kiss.md
@@ -0,0 +1,5 @@
+---
+"@google/generative-ai": minor
+---
+
+Add ability to set modelParams (generationConfig, safetySettings) on getGenerativeModelFromCachedContent().
diff --git a/common/api-review/generative-ai.api.md b/common/api-review/generative-ai.api.md
index 448d096d..7bc7d3f4 100644
--- a/common/api-review/generative-ai.api.md
+++ b/common/api-review/generative-ai.api.md
@@ -481,7 +481,7 @@ export class GoogleGenerativeAI {
     // (undocumented)
     apiKey: string;
     getGenerativeModel(modelParams: ModelParams, requestOptions?: RequestOptions): GenerativeModel;
-    getGenerativeModelFromCachedContent(cachedContent: CachedContent, requestOptions?: RequestOptions): GenerativeModel;
+    getGenerativeModelFromCachedContent(cachedContent: CachedContent, modelParams?: Partial<ModelParams>, requestOptions?: RequestOptions): GenerativeModel;
 }
 
 // @public
diff --git a/docs/reference/main/generative-ai.googlegenerativeai.getgenerativemodelfromcachedcontent.md b/docs/reference/main/generative-ai.googlegenerativeai.getgenerativemodelfromcachedcontent.md
index 1f24640f..354cd072 100644
--- a/docs/reference/main/generative-ai.googlegenerativeai.getgenerativemodelfromcachedcontent.md
+++ b/docs/reference/main/generative-ai.googlegenerativeai.getgenerativemodelfromcachedcontent.md
@@ -9,7 +9,7 @@ Creates a [GenerativeModel](./generative-ai.generativemodel.md) instance from pr
 **Signature:**
 
 ```typescript
-getGenerativeModelFromCachedContent(cachedContent: CachedContent, requestOptions?: RequestOptions): GenerativeModel;
+getGenerativeModelFromCachedContent(cachedContent: CachedContent, modelParams?: Partial<ModelParams>, requestOptions?: RequestOptions): GenerativeModel;
 ```
 
 ## Parameters
@@ -17,6 +17,7 @@ getGenerativeModelFromCachedContent(cachedContent: CachedContent, requestOptions
 |  Parameter | Type | Description |
 |  --- | --- | --- |
 |  cachedContent | [CachedContent](./generative-ai.cachedcontent.md) |  |
+|  modelParams | Partial&lt;[ModelParams](./generative-ai.modelparams.md)<!-- -->&gt; | _(Optional)_ |
 |  requestOptions | [RequestOptions](./generative-ai.requestoptions.md) | _(Optional)_ |
 
 **Returns:**
diff --git a/docs/reference/main/generative-ai.googlegenerativeai.md b/docs/reference/main/generative-ai.googlegenerativeai.md
index 0f3aa381..38bad256 100644
--- a/docs/reference/main/generative-ai.googlegenerativeai.md
+++ b/docs/reference/main/generative-ai.googlegenerativeai.md
@@ -29,5 +29,5 @@ export declare class GoogleGenerativeAI
 |  Method | Modifiers | Description |
 |  --- | --- | --- |
 |  [getGenerativeModel(modelParams, requestOptions)](./generative-ai.googlegenerativeai.getgenerativemodel.md) |  | Gets a [GenerativeModel](./generative-ai.generativemodel.md) instance for the provided model name. |
-|  [getGenerativeModelFromCachedContent(cachedContent, requestOptions)](./generative-ai.googlegenerativeai.getgenerativemodelfromcachedcontent.md) |  | Creates a [GenerativeModel](./generative-ai.generativemodel.md) instance from provided content cache. |
+|  [getGenerativeModelFromCachedContent(cachedContent, modelParams, requestOptions)](./generative-ai.googlegenerativeai.getgenerativemodelfromcachedcontent.md) |  | Creates a [GenerativeModel](./generative-ai.generativemodel.md) instance from provided content cache. |
 
diff --git a/src/gen-ai.test.ts b/src/gen-ai.test.ts
index 9e8972e9..fd17aa4e 100644
--- a/src/gen-ai.test.ts
+++ b/src/gen-ai.test.ts
@@ -18,17 +18,104 @@ import { ModelParams } from "../types";
 import { GenerativeModel, GoogleGenerativeAI } from "./gen-ai";
 import { expect } from "chai";
 
+const fakeContents = [{ role: "user", parts: [{ text: "hello" }] }];
+
+const fakeCachedContent = {
+  model: "my-model",
+  name: "mycachename",
+  contents: fakeContents,
+};
+
 describe("GoogleGenerativeAI", () => {
-  it("genGenerativeInstance throws if no model is provided", () => {
+  it("getGenerativeModel throws if no model is provided", () => {
     const genAI = new GoogleGenerativeAI("apikey");
     expect(() => genAI.getGenerativeModel({} as ModelParams)).to.throw(
       "Must provide a model name",
     );
   });
-  it("genGenerativeInstance gets a GenerativeModel", () => {
+  it("getGenerativeModel gets a GenerativeModel", () => {
     const genAI = new GoogleGenerativeAI("apikey");
     const genModel = genAI.getGenerativeModel({ model: "my-model" });
     expect(genModel).to.be.an.instanceOf(GenerativeModel);
     expect(genModel.model).to.equal("models/my-model");
   });
+  it("getGenerativeModelFromCachedContent gets a GenerativeModel", () => {
+    const genAI = new GoogleGenerativeAI("apikey");
+    const genModel =
+      genAI.getGenerativeModelFromCachedContent(fakeCachedContent);
+    expect(genModel).to.be.an.instanceOf(GenerativeModel);
+    expect(genModel.model).to.equal("models/my-model");
+    expect(genModel.cachedContent).to.eql(fakeCachedContent);
+  });
+  it("getGenerativeModelFromCachedContent gets a GenerativeModel merged with modelParams", () => {
+    const genAI = new GoogleGenerativeAI("apikey");
+    const genModel = genAI.getGenerativeModelFromCachedContent(
+      fakeCachedContent,
+      { generationConfig: { temperature: 0 } },
+    );
+    expect(genModel).to.be.an.instanceOf(GenerativeModel);
+    expect(genModel.model).to.equal("models/my-model");
+    expect(genModel.generationConfig.temperature).to.equal(0);
+    expect(genModel.cachedContent).to.eql(fakeCachedContent);
+  });
+  it("getGenerativeModelFromCachedContent gets a GenerativeModel merged with modelParams with overlapping keys", () => {
+    const genAI = new GoogleGenerativeAI("apikey");
+    const genModel = genAI.getGenerativeModelFromCachedContent(
+      fakeCachedContent,
+      { model: "my-model", generationConfig: { temperature: 0 } },
+    );
+    expect(genModel).to.be.an.instanceOf(GenerativeModel);
+    expect(genModel.model).to.equal("models/my-model");
+    expect(genModel.generationConfig.temperature).to.equal(0);
+    expect(genModel.cachedContent).to.eql(fakeCachedContent);
+  });
+  it("getGenerativeModelFromCachedContent throws if no name", () => {
+    const genAI = new GoogleGenerativeAI("apikey");
+    expect(() =>
+      genAI.getGenerativeModelFromCachedContent({
+        model: "my-model",
+        contents: fakeContents,
+      }),
+    ).to.throw("Cached content must contain a `name` field.");
+  });
+  it("getGenerativeModelFromCachedContent throws if no model", () => {
+    const genAI = new GoogleGenerativeAI("apikey");
+    expect(() =>
+      genAI.getGenerativeModelFromCachedContent({
+        name: "cachename",
+        contents: fakeContents,
+      }),
+    ).to.throw("Cached content must contain a `model` field.");
+  });
+  it("getGenerativeModelFromCachedContent throws if mismatched model", () => {
+    const genAI = new GoogleGenerativeAI("apikey");
+    expect(() =>
+      genAI.getGenerativeModelFromCachedContent(
+        {
+          name: "cachename",
+          model: "my-model",
+          contents: fakeContents,
+        },
+        { model: "your-model" },
+      ),
+    ).to.throw(
+      `Different value for "model" specified in modelParams (your-model) and cachedContent (my-model)`,
+    );
+  });
+  it("getGenerativeModelFromCachedContent throws if mismatched systemInstruction", () => {
+    const genAI = new GoogleGenerativeAI("apikey");
+    expect(() =>
+      genAI.getGenerativeModelFromCachedContent(
+        {
+          name: "cachename",
+          model: "my-model",
+          contents: fakeContents,
+          systemInstruction: "hi",
+        },
+        { model: "models/my-model", systemInstruction: "yo" },
+      ),
+    ).to.throw(
+      `Different value for "systemInstruction" specified in modelParams (yo) and cachedContent (hi)`,
+    );
+  });
 });
diff --git a/src/gen-ai.ts b/src/gen-ai.ts
index 2cc34703..f65f489d 100644
--- a/src/gen-ai.ts
+++ b/src/gen-ai.ts
@@ -53,6 +53,7 @@ export class GoogleGenerativeAI {
    */
   getGenerativeModelFromCachedContent(
     cachedContent: CachedContent,
+    modelParams?: Partial<ModelParams>,
     requestOptions?: RequestOptions,
   ): GenerativeModel {
     if (!cachedContent.name) {
@@ -65,7 +66,40 @@ export class GoogleGenerativeAI {
         "Cached content must contain a `model` field.",
       );
     }
+
+    /**
+     * Not checking tools and toolConfig for now as it would require a deep
+     * equality comparison and isn't likely to be a common case.
+     */
+    const disallowedDuplicates: Array<keyof ModelParams & keyof CachedContent> =
+      ["model", "systemInstruction"];
+
+    for (const key of disallowedDuplicates) {
+      if (
+        modelParams?.[key] &&
+        cachedContent[key] &&
+        modelParams?.[key] !== cachedContent[key]
+      ) {
+        if (key === "model") {
+          const modelParamsComp = modelParams.model.startsWith("models/")
+            ? modelParams.model.replace("models/", "")
+            : modelParams.model;
+          const cachedContentComp = cachedContent.model.startsWith("models/")
+            ? cachedContent.model.replace("models/", "")
+            : cachedContent.model;
+          if (modelParamsComp === cachedContentComp) {
+            continue;
+          }
+        }
+        throw new GoogleGenerativeAIRequestInputError(
+          `Different value for "${key}" specified in modelParams` +
+            ` (${modelParams[key]}) and cachedContent (${cachedContent[key]})`,
+        );
+      }
+    }
+
     const modelParamsFromCache: ModelParams = {
+      ...modelParams,
       model: cachedContent.model,
       tools: cachedContent.tools,
       toolConfig: cachedContent.toolConfig,