diff --git a/core/src/components/item-option/item-option.scss b/core/src/components/item-option/item-option.scss
index b01024e6ece..56cb1138aba 100644
--- a/core/src/components/item-option/item-option.scss
+++ b/core/src/components/item-option/item-option.scss
@@ -17,18 +17,6 @@
   font-family: $font-family-base;
 }
 
-:host(.in-list.item-options-end:last-child) {
-  @include padding-horizontal(
-    null, calc(.7em + var(--ion-safe-area-right))
-  );
-}
-
-:host(.in-list.item-options-start:first-child) {
-  @include padding-horizontal(
-    calc(.7em + var(--ion-safe-area-left)), null
-  );
-}
-
 :host(.ion-color) {
   background: current-color(base);
   color: current-color(contrast);
diff --git a/core/src/components/item-sliding/test/basic/item-sliding.e2e.ts b/core/src/components/item-sliding/test/basic/item-sliding.e2e.ts
index 3d31279b40c..908155f0ea5 100644
--- a/core/src/components/item-sliding/test/basic/item-sliding.e2e.ts
+++ b/core/src/components/item-sliding/test/basic/item-sliding.e2e.ts
@@ -99,3 +99,94 @@ configs({ modes: ['md'], directions: ['ltr'] }).forEach(({ title, screenshot, co
     });
   });
 });
+
+/**
+ * This behavior needs to be tested in both modes and directions to
+ * make sure the safe area padding is applied only to that side
+ * regardless of direction
+ */
+configs().forEach(({ title, screenshot, config }) => {
+  test.describe(title('item-sliding: basic'), () => {
+    test.describe('safe area left', () => {
+      test('should have padding on the left only', async ({ page }) => {
+        await page.setContent(
+          `
+          <style>
+            :root {
+              --ion-safe-area-left: 40px;
+            }
+          </style>
+
+          <ion-item-sliding>
+            <ion-item-options side="start">
+              <ion-item-option color="primary">
+                Archive
+              </ion-item-option>
+              <ion-item-option color="danger">
+                Delete
+              </ion-item-option>
+            </ion-item-options>
+
+            <ion-item>
+              <ion-label>
+                Sliding Item
+              </ion-label>
+            </ion-item>
+          </ion-item-sliding>
+        `,
+          config
+        );
+
+        const direction = config.direction;
+        const item = page.locator('ion-item-sliding');
+
+        const dragByX = direction == 'rtl' ? -150 : 150;
+        await dragElementBy(item, page, dragByX);
+        await page.waitForChanges();
+
+        await expect(item).toHaveScreenshot(screenshot(`item-sliding-safe-area-left`));
+      });
+    });
+
+    test.describe('safe area right', () => {
+      test('should have padding on the right only', async ({ page }) => {
+        await page.setContent(
+          `
+          <style>
+            :root {
+              --ion-safe-area-right: 40px;
+            }
+          </style>
+
+          <ion-item-sliding>
+            <ion-item>
+              <ion-label>
+                Sliding Item
+              </ion-label>
+            </ion-item>
+
+            <ion-item-options side="end">
+              <ion-item-option color="primary">
+                Archive
+              </ion-item-option>
+              <ion-item-option color="danger">
+                Delete
+              </ion-item-option>
+            </ion-item-options>
+          </ion-item-sliding>
+        `,
+          config
+        );
+
+        const direction = config.direction;
+        const item = page.locator('ion-item-sliding');
+
+        const dragByX = direction == 'rtl' ? 150 : -150;
+        await dragElementBy(item, page, dragByX);
+        await page.waitForChanges();
+
+        await expect(item).toHaveScreenshot(screenshot(`item-sliding-safe-area-right`));
+      });
+    });
+  });
+});
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