diff --git a/pex/scie/__init__.py b/pex/scie/__init__.py
index 9d1c81a21..9523f9fc5 100644
--- a/pex/scie/__init__.py
+++ b/pex/scie/__init__.py
@@ -187,6 +187,23 @@ def register_options(parser):
             "less than half the size of the distributions that ship with debug symbols."
         ),
     )
+    parser.add_argument(
+        "--scie-hash-alg",
+        dest="scie_hash_algorithms",
+        default=[],
+        action="append",
+        type=str,
+        help=(
+            "Output a checksum file for each scie generated that is compatible with the shasum "
+            "family of tools. For each unique --scie-hash-alg specified, a sibling file to each "
+            "scie executable will be generated with the same stem as that scie file and hash "
+            "algorithm name suffix. The file will contain the hex fingerprint of the scie "
+            "executable using that algorithm to hash it. Supported algorithms include at least "
+            "md5, sha1, sha256, sha384 and sha512. For the complete list of supported hash "
+            "algorithms, see the science tool --hash documentation here: "
+            "https://science.scie.app/cli.html#science-lift-build."
+        ),
+    )
     parser.add_argument(
         "--scie-science-binary",
         dest="scie_science_binary",
@@ -225,6 +242,9 @@ def render_options(options):
         args.append(".".join(map(str, options.python_version)))
     if options.pbs_stripped:
         args.append("--scie-pbs-stripped")
+    for hash_algorithm in options.hash_algorithms:
+        args.append("--scie-hash-alg")
+        args.append(hash_algorithm)
     if options.science_binary:
         args.append("--scie-science-binary")
         args.append(options.science_binary)
@@ -310,6 +330,7 @@ def extract_options(options):
         pypy_release=options.scie_pypy_release,
         python_version=python_version,
         pbs_stripped=options.scie_pbs_stripped,
+        hash_algorithms=tuple(options.scie_hash_algorithms),
         science_binary=science_binary,
     )
 
diff --git a/pex/scie/model.py b/pex/scie/model.py
index 5c6a31b53..0d7218ce9 100644
--- a/pex/scie/model.py
+++ b/pex/scie/model.py
@@ -355,6 +355,7 @@ class ScieOptions(object):
         default=None
     )  # type: Optional[Union[Tuple[int, int], Tuple[int, int, int]]]
     pbs_stripped = attr.ib(default=False)  # type: bool
+    hash_algorithms = attr.ib(default=())  # type: Tuple[str, ...]
     science_binary = attr.ib(default=None)  # type: Optional[Union[File, Url]]
 
     def create_configuration(self, targets):
diff --git a/pex/scie/science.py b/pex/scie/science.py
index 8e1b3a83d..6c6753b34 100644
--- a/pex/scie/science.py
+++ b/pex/scie/science.py
@@ -442,6 +442,8 @@ def build(
         )
         if use_platform_suffix:
             args.append("--use-platform-suffix")
+        for hash_algorithm in configuration.options.hash_algorithms:
+            args.extend(["--hash", hash_algorithm])
         args.append(manifest.path)
         with open(os.devnull, "wb") as devnull:
             process = subprocess.Popen(args=args, stdout=devnull, stderr=subprocess.PIPE)
diff --git a/tests/integration/scie/test_pex_scie.py b/tests/integration/scie/test_pex_scie.py
index 16d3e592f..f3f7c5c9e 100644
--- a/tests/integration/scie/test_pex_scie.py
+++ b/tests/integration/scie/test_pex_scie.py
@@ -100,6 +100,49 @@ def test_basic(
     assert b"| PAR! |" in subprocess.check_output(args=[scie, "PAR!"], env=make_env(PATH=None))
 
 
+@pytest.mark.skipif(
+    PY_VER < (3, 8) and not IS_PYPY,
+    reason="Scie output is not supported for {interpreter}".format(interpreter=sys.version),
+)
+@pytest.mark.skipif(
+    not any(
+        is_exe(os.path.join(entry, "shasum"))
+        for entry in os.environ.get("PATH", os.path.defpath).split(os.pathsep)
+    ),
+    reason="This test requires the `shasum` utility be available on the PATH.",
+)
+def test_hashes(tmpdir):
+    # type: (Any) -> None
+
+    pex = os.path.join(str(tmpdir), "cowsay")
+    run_pex_command(
+        args=[
+            "cowsay==5.0",
+            "-c",
+            "cowsay",
+            "-o",
+            pex,
+            "--scie",
+            "lazy",
+            "--scie-hash-alg",
+            "sha256",
+            "--scie-hash-alg",
+            "sha512",
+        ]
+    ).assert_success()
+
+    assert b"| PEX-scie wabbit! |" in subprocess.check_output(
+        args=[pex, "PEX-scie wabbit!"], env=make_env(PATH=None)
+    )
+
+    for alg in "sha256", "sha512":
+        shasum_file = "{pex}.{alg}".format(pex=pex, alg=alg)
+        assert os.path.exists(shasum_file), "Expected {shasum_file} to be generated.".format(
+            shasum_file=shasum_file
+        )
+        subprocess.check_call(args=["shasum", "-c", os.path.basename(shasum_file)], cwd=str(tmpdir))
+
+
 def test_multiple_platforms(tmpdir):
     # type: (Any) -> None