diff --git a/Lib/test/test_typing.py b/Lib/test/test_typing.py
index e36cab601621e3..6b2756561fbb0b 100644
--- a/Lib/test/test_typing.py
+++ b/Lib/test/test_typing.py
@@ -6756,10 +6756,29 @@ class Wrong(*bases):
                         pass
 
     def test_is_typeddict(self):
-        assert is_typeddict(Point2D) is True
-        assert is_typeddict(Union[str, int]) is False
+        self.assertIs(is_typeddict(Point2D), True)
+        self.assertIs(is_typeddict(Union[str, int]), False)
         # classes, not instances
-        assert is_typeddict(Point2D()) is False
+        self.assertIs(is_typeddict(Point2D()), False)
+        call_based = TypedDict('call_based', {'a': int})
+        self.assertIs(is_typeddict(call_based), True)
+        self.assertIs(is_typeddict(call_based()), False)
+
+        T = TypeVar("T")
+        class BarGeneric(TypedDict, Generic[T]):
+            a: T
+        self.assertIs(is_typeddict(BarGeneric), True)
+        self.assertIs(is_typeddict(BarGeneric[int]), False)
+        self.assertIs(is_typeddict(BarGeneric()), False)
+
+        class NewGeneric[T](TypedDict):
+            a: T
+        self.assertIs(is_typeddict(NewGeneric), True)
+        self.assertIs(is_typeddict(NewGeneric[int]), False)
+        self.assertIs(is_typeddict(NewGeneric()), False)
+
+        # The TypedDict constructor is not itself a TypedDict
+        self.assertIs(is_typeddict(TypedDict), False)
 
     def test_get_type_hints(self):
         self.assertEqual(