diff --git a/subsets/ro-chado.obo b/subsets/ro-chado.obo new file mode 100644 index 00000000..69ef8e09 --- /dev/null +++ b/subsets/ro-chado.obo @@ -0,0 +1,3039 @@ +format-version: 1.2 +subsetdef: ro-eco "" +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 61 Logical Axioms: 0] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 53 Logical Axioms: 12] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 276 Logical Axioms: 56] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 6 Logical Axioms: 2] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 42 Logical Axioms: 16] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 29 Logical Axioms: 9] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 20 Logical Axioms: 6] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 731 Logical Axioms: 148] +remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 146 Logical Axioms: 45] +default-namespace: ro +ontology: ro/subsets/ro-chado.obo +property_value: http://purl.org/dc/elements/1.1/description "The OBO Relations Ontology (RO) is a collection of OWL relations (ObjectProperties) intended for use across a wide variety of biological ontologies." xsd:string +property_value: http://purl.org/dc/elements/1.1/source http://obofoundry.org/ro +property_value: http://purl.org/dc/elements/1.1/title "OBO Relations Ontology" xsd:string +property_value: http://xmlns.com/foaf/0.1/homepage " https://github.com/oborel/obo-relations/" xsd:anyURI + +[Typedef] +id: BFO:0000050 +name: part_of +def: "a core relation that holds between a part and its whole" [] +is_transitive: true +is_a: RO:0002131 ! overlaps +inverse_of: BFO:0000051 ! has part + +[Typedef] +id: BFO:0000051 +name: has_part +def: "a core relation that holds between a whole and its part" [] +is_transitive: true +is_a: RO:0002131 ! overlaps + +[Typedef] +id: BFO:0000054 +name: realized_in + +[Typedef] +id: BFO:0000055 +name: realizes +inverse_of: BFO:0000054 ! realized in + +[Typedef] +id: BFO:0000060 +name: obsolete_preceded_by +is_transitive: true + +[Typedef] +id: BFO:0000062 +name: preceded_by +def: "x is preceded by y if and only if the time point at which y ends is before or equivalent to the time point at which x starts. Formally: x preceded by y iff ω(y) <= α(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] +holds_over_chain: BFO:0000050 BFO:0000062 +holds_over_chain: RO:0002091 BFO:0000062 +holds_over_chain: RO:0002092 BFO:0000062 +is_transitive: true +is_a: RO:0002086 ! ends after +inverse_of: BFO:0000063 ! precedes + +[Typedef] +id: BFO:0000063 +name: precedes +def: "x precedes y if and only if the time point at which x ends is before or equivalent to the time point at which y starts. Formally: x precedes y iff ω(x) <= α(y), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] +holds_over_chain: BFO:0000050 BFO:0000063 +holds_over_chain: RO:0002092 BFO:0000063 +is_transitive: true +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: BFO:0000066 +name: occurs_in +def: "b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] +holds_over_chain: BFO:0000050 BFO:0000066 +inverse_of: BFO:0000067 ! contains process +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: BFO:0000067 +name: contains_process +def: "[copied from inverse property 'occurs in'] b occurs_in c =def b is a process and c is a material entity or immaterial entity& there exists a spatiotemporal region r and b occupies_spatiotemporal_region r.& forall(t) if b exists_at t then c exists_at t & there exist spatial regions s and s’ where & b spatially_projects_onto s at t& c is occupies_spatial_region s’ at t& s is a proper_continuant_part_of s’ at t" [] + +[Typedef] +id: RO:0000052 +name: inheres_in +def: "a relation between a specifically dependent continuant (the dependent) and an independent continuant (the bearer), in which the dependent specifically depends on the bearer for its existence" [] +is_a: RO:0002314 ! inheres in part of + +[Typedef] +id: RO:0000053 +name: bearer_of +def: "a relation between an independent continuant (the bearer) and a specifically dependent continuant (the dependent), in which the dependent specifically depends on the bearer for its existence" [] +inverse_of: RO:0000052 ! inheres in + +[Typedef] +id: RO:0000056 +name: participates_in +def: "a relation between a continuant and a process, in which the continuant is somehow involved in the process" [] + +[Typedef] +id: RO:0000057 +name: has_participant +def: "a relation between a process and a continuant, in which the continuant is somehow involved in the process" [] +holds_over_chain: BFO:0000051 RO:0000057 +inverse_of: RO:0000056 ! participates in + +[Typedef] +id: RO:0000058 +name: is_concretized_as +def: "A relationship between a generically dependent continuant and a specifically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. A generically dependent continuant may be concretized as multiple specifically dependent continuants." [] + +[Typedef] +id: RO:0000059 +name: concretizes +def: "A relationship between a specifically dependent continuant and a generically dependent continuant, in which the generically dependent continuant depends on some independent continuant in virtue of the fact that the specifically dependent continuant also depends on that same independent continuant. Multiple specifically dependent continuants can concretize the same generically dependent continuant." [] +inverse_of: RO:0000058 ! is concretized as + +[Typedef] +id: RO:0000079 +name: function_of +def: "a relation between a function and an independent continuant (the bearer), in which the function specifically depends on the bearer for its existence" [] +is_a: RO:0000052 ! inheres in +inverse_of: RO:0000085 ! has function + +[Typedef] +id: RO:0000080 +name: quality_of +def: "a relation between a quality and an independent continuant (the bearer), in which the quality specifically depends on the bearer for its existence" [] +is_a: RO:0000052 ! inheres in +inverse_of: RO:0000086 ! has quality + +[Typedef] +id: RO:0000081 +name: role_of +def: "a relation between a role and an independent continuant (the bearer), in which the role specifically depends on the bearer for its existence" [] +is_a: RO:0000052 ! inheres in + +[Typedef] +id: RO:0000085 +name: has_function +def: "a relation between an independent continuant (the bearer) and a function, in which the function specifically depends on the bearer for its existence" [] +is_a: RO:0000053 ! bearer of + +[Typedef] +id: RO:0000086 +name: has_quality +def: "a relation between an independent continuant (the bearer) and a quality, in which the quality specifically depends on the bearer for its existence" [] +is_a: RO:0000053 ! bearer of + +[Typedef] +id: RO:0000087 +name: has_role +def: "a relation between an independent continuant (the bearer) and a role, in which the role specifically depends on the bearer for its existence" [] +is_a: RO:0000053 ! bearer of +inverse_of: RO:0000081 ! role of + +[Typedef] +id: RO:0000091 +name: has_disposition +def: "a relation between an independent continuant (the bearer) and a disposition, in which the disposition specifically depends on the bearer for its existence" [] +is_a: RO:0000053 ! bearer of + +[Typedef] +id: RO:0000092 +name: disposition_of +is_a: RO:0000052 ! inheres in +inverse_of: RO:0000091 ! has disposition + +[Typedef] +id: RO:0000300 +name: in_neural_circuit_with +def: "A relation that holds between two neurons connected directly via a synapse, or indirectly via a series of synaptically connected neurons." [] +is_transitive: true + +[Typedef] +id: RO:0000301 +name: upstream_in_neural_circuit_with +def: "A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next." [] +is_transitive: true +is_a: RO:0000300 ! in neural circuit with + +[Typedef] +id: RO:0000302 +name: downstream_in_neural_circuit_with +def: "A relation that holds between a neuron that is synapsed_to another neuron or a neuron that is connected indirectly to another by a chain of neurons, each synapsed_to the next." [] +is_transitive: true +is_a: RO:0000300 ! in neural circuit with + +[Typedef] +id: RO:0001000 +name: derives_from +def: "a relation between two distinct material entities, the new entity and the old entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] + +[Typedef] +id: RO:0001001 +name: derives_into +def: "a relation between two distinct material entities, the old entity and the new entity, in which the new entity begins to exist when the old entity ceases to exist, and the new entity inherits the significant portion of the matter of the old entity" [] +inverse_of: RO:0001000 ! derives from + +[Typedef] +id: RO:0001015 +name: location_of +def: "a relation between two independent continuants, the location and the target, in which the target is entirely within the location" [] +is_transitive: true + +[Typedef] +id: RO:0001018 +name: contained_in +holds_over_chain: RO:0001025 BFO:0000050 +inverse_of: RO:0001019 ! contains + +[Typedef] +id: RO:0001019 +name: contains + +[Typedef] +id: RO:0001025 +name: located_in +def: "a relation between two independent continuants, the target and the location, in which the target is entirely within the location" [] +is_transitive: true +inverse_of: RO:0001015 ! location of + +[Typedef] +id: RO:0002000 +name: 2D_boundary_of +def: "a relation between a 2D immaterial entity (the boundary) and a material entity, in which the boundary delimits the material entity" [] +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002001 +name: aligned_with +is_transitive: true + +[Typedef] +id: RO:0002002 +name: has_2D_boundary +def: "a relation between a material entity and a 2D immaterial entity (the boundary), in which the boundary delimits the material entity" [] +is_a: RO:0002323 ! mereotopologically related to +inverse_of: RO:0002000 ! 2D boundary of + +[Typedef] +id: RO:0002003 +name: electrically_synapsed_to +def: "A relation that holds between two neurons that are electrically coupled via gap junctions." [] +is_a: RO:0000300 ! in neural circuit with + +[Typedef] +id: RO:0002004 +name: tracheates +def: "The relationship that holds between a trachea or tracheole and an antomical structure that is contained in (and so provides an oxygen supply to)." [] +is_a: RO:0001018 ! contained in + +[Typedef] +id: RO:0002005 +name: innervated_by +inverse_of: RO:0002134 ! innervates + +[Typedef] +id: RO:0002006 +name: has_synaptic_terminal_of +is_a: RO:0002131 ! overlaps +inverse_of: RO:0002130 ! has synaptic terminal in + +[Typedef] +id: RO:0002007 +name: bounding_layer_of +def: "X outer_layer_of Y iff:\n. X :continuant that bearer_of some PATO:laminar\n. X part_of Y\n. exists Z :surface\n. X has_boundary Z\n. Z boundary_of Y\n\nhas_boundary: http://purl.obolibrary.org/obo/RO_0002002\nboundary_of: http://purl.obolibrary.org/obo/RO_0002000" [] +is_a: BFO:0000050 ! part of + +[Typedef] +id: RO:0002008 +name: coincident_with +def: "A relation that holds between two linear structures that are approximately parallel to each other for their entire length and where either the two structures are adjacent to each other or one is part of the other." [] +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002009 +name: cell_expresses +def: "A relation that applies between a cell(c) and a gene(g) , where the process of 'transcription, DNA templated (GO_0006351)' is occuring in in cell c and that process has input gene g." [] +is_a: RO:0002292 ! expresses + +[Typedef] +id: RO:0002010 +name: regulates_in_other_organism +def: "x 'regulates in other organism' y if and only if: (x is the realization of a function to exert an effect on the frequency, rate or extent of y) AND (the agents of x are produced by organism o1 and the agents of y are produced by organism o2)." [] +is_a: RO:0002418 ! causally upstream of or within + +[Typedef] +id: RO:0002011 +name: regulates_transport_of +def: "A relationship that holds between a process that regulates a transport process and the entity transported by that process." [GOC:dos] +holds_over_chain: RO:0002211 RO:0002313 + +[Typedef] +id: RO:0002081 +name: before_or_simultaneous_with +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: RO:0002082 +name: simultaneous_with +is_transitive: true +is_a: RO:0002081 ! before or simultaneous with + +[Typedef] +id: RO:0002083 +name: before +is_transitive: true +is_a: RO:0002081 ! before or simultaneous with + +[Typedef] +id: RO:0002084 +name: during_which_ends +is_a: RO:0002222 ! temporally related to +inverse_of: RO:0002093 ! ends during + +[Typedef] +id: RO:0002085 +name: encompasses +is_transitive: true +is_a: RO:0002088 ! during which starts +inverse_of: RO:0002092 ! happens during + +[Typedef] +id: RO:0002086 +name: ends_after +holds_over_chain: RO:0002093 BFO:0000062 +is_transitive: true +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: RO:0002087 +name: immediately_preceded_by +holds_over_chain: RO:0002224 RO:0002230 +is_a: BFO:0000062 ! preceded by +inverse_of: RO:0002090 ! immediately precedes + +[Typedef] +id: RO:0002088 +name: during_which_starts +is_a: RO:0002222 ! temporally related to +inverse_of: RO:0002091 ! starts during + +[Typedef] +id: RO:0002089 +name: starts_before +holds_over_chain: RO:0002091 BFO:0000060 +is_transitive: true +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: RO:0002090 +name: immediately_precedes +holds_over_chain: RO:0002230 RO:0002224 +is_a: BFO:0000063 ! precedes + +[Typedef] +id: RO:0002091 +name: starts_during +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: RO:0002092 +name: happens_during +is_transitive: true +is_a: RO:0002093 ! ends during + +[Typedef] +id: RO:0002093 +name: ends_during +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: RO:0002100 +name: has_soma_location +def: "Relation between a neuron and an anatomical structure that its soma is part of." [] +is_a: RO:0002131 ! overlaps +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002101 +name: fasciculates_with +def: "relationship between a neuron and a neuron projection bundle (e.g.- tract or nerve bundle) that one or more of its projections travels through.\n" [] +is_a: RO:0002131 ! overlaps + +[Typedef] +id: RO:0002102 +name: axon_synapses_in +def: "Relation between a neuron and some structure its axon forms (chemical) synapses in." [] +is_a: RO:0002113 ! has presynaptic terminal in +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002103 +name: synapsed_by +def: "Relation between an anatomical structure (including cells) and a neuron that chemically synapses to it. " [] +is_a: RO:0000301 ! upstream in neural circuit with +inverse_of: RO:0002120 ! synapsed to + +[Typedef] +id: RO:0002104 +name: has_plasma_membrane_part +def: "Holds between a cell c and a protein complex or protein p if and only if that cell has as part a plasma_membrane[GO:0005886], and that plasma membrane has p as part." [] +is_a: BFO:0000051 ! has part + +[Typedef] +id: RO:0002105 +name: synapsed_via_type_Ib_bouton_to +def: "A relation between a motor neuron and a muscle that it synapses to via a type Ib bouton." [] +is_a: RO:0002120 ! synapsed to +inverse_of: RO:0002109 ! synapsed_by_via_type_Ib_bouton + +[Typedef] +id: RO:0002106 +name: synapsed_via_type_Is_bouton_to +def: "A relation between a motor neuron and a muscle that it synapses to via a type Is bouton." [] +is_a: RO:0002120 ! synapsed to +inverse_of: RO:0002112 ! synapsed_by_via_type_Is_bouton + +[Typedef] +id: RO:0002107 +name: synapsed_via_type_II_bouton_to +def: "A relation between a motor neuron and a muscle that it synapses to via a type II bouton." [] +is_a: RO:0002120 ! synapsed to +inverse_of: RO:0002108 ! synapsed_by_via_type_II_bouton + +[Typedef] +id: RO:0002108 +name: synapsed_by_via_type_II_bouton +def: "Relation between a muscle and a motor neuron that synapses to it via a type II bouton." [] +is_a: RO:0002103 ! synapsed by + +[Typedef] +id: RO:0002109 +name: synapsed_by_via_type_Ib_bouton +def: "Relation between a muscle and a motor neuron that synapses to it via a type Ib bouton." [] +is_a: RO:0002103 ! synapsed by + +[Typedef] +id: RO:0002110 +name: has_postsynaptic_terminal_in +def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input. " [] +is_a: RO:0002130 ! has synaptic terminal in +inverse_of: RO:0002102 ! axon synapses in +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002111 +name: releases_neurotransmitter + +[Typedef] +id: RO:0002112 +name: synapsed_by_via_type_Is_bouton +def: "Relation between a muscle and a motor neuron that synapses to it via a type Is bouton." [] +is_a: RO:0002103 ! synapsed by + +[Typedef] +id: RO:0002113 +name: has_presynaptic_terminal_in +def: "Relation between a neuron and some structure (e.g.- a brain region) in which it receives (chemical) synaptic input." [] +is_a: RO:0002130 ! has synaptic terminal in +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002114 +name: synapsed_via_type_III_bouton_to +def: "A relation between a motor neuron and a muscle that it synapses to via a type III bouton." [] +is_a: RO:0002120 ! synapsed to +inverse_of: RO:0002115 ! synapsed_by_via_type_III_bouton + +[Typedef] +id: RO:0002115 +name: synapsed_by_via_type_III_bouton +def: "Relation between a muscle and a motor neuron that synapses to it via a type III bouton.\n" [] +is_a: RO:0002103 ! synapsed by + +[Typedef] +id: RO:0002120 +name: synapsed_to +def: " Relation between a neuron and an anatomical structure (including cells) that it chemically synapses to.\n " [] +is_a: RO:0000302 ! downstream in neural circuit with + +[Typedef] +id: RO:0002121 +name: dendrite_synapsed_in +def: "Relation between a neuron and some structure (e.g.- a brain region) in which its dendrite receives synaptic input.\n\n " [] +is_a: RO:0002110 ! has postsynaptic terminal in +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002130 +name: has_synaptic_terminal_in +def: "A general relation between a neuron and some structure in which it either chemically synapses to some target or in which it receives (chemical) synaptic input." [] +is_a: RO:0002131 ! overlaps +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002131 +name: overlaps +def: "x overlaps y if and only if there exists some z such that x has part z and z part of y" [] +holds_over_chain: BFO:0000050 BFO:0000050 +holds_over_chain: BFO:0000051 BFO:0000050 {http://purl.obolibrary.org/obo/RO_0002582="true"} +holds_over_chain: BFO:0000051 RO:0002131 +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002132 +name: has_fasciculating_neuron_projection +def: "The relation between a neuron projection bundle and a neuron projection that is fasciculated with it." [] +is_a: RO:0002131 ! overlaps +inverse_of: RO:0002101 ! fasciculates with + +[Typedef] +id: RO:0002134 +name: innervates +def: "Relation between a 'neuron projection bundle' and a region in which one or more of its component neuron projections either synapses to targets or receives synaptic input.\nT innervates some R\nExpands_to: T has_fasciculating_neuron_projection that synapse_in some R." [] +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002150 +name: continuous_with +def: "X continuous_with Y if and only if X and Y share a fiat boundary." [] +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002151 +name: partially_overlaps +def: "x partially overlaps y iff there exists some z such that z is part of x and z is part of y, and it is also the case that neither x is part of y or y is part of x" [] +is_a: RO:0002131 ! overlaps + +[Typedef] +id: RO:0002156 +name: derived_by_descent_from +def: "d derived_by_descent_from a if d is specified by some genetic program that is sequence-inherited-from a genetic program that specifies a." [] +is_transitive: true +is_a: RO:0002320 ! evolutionarily related to +inverse_of: RO:0002157 ! has derived by descendant + +[Typedef] +id: RO:0002157 +name: has_derived_by_descendant +is_transitive: true +is_a: RO:0002320 ! evolutionarily related to + +[Typedef] +id: RO:0002158 +name: shares_ancestor_with +def: "two individual entities d1 and d2 stand in a shares_ancestor_with relation if and only if there exists some a such that d1 derived_by_descent_from a and d2 derived_by_descent_from a." [] +holds_over_chain: RO:0002156 RO:0002157 +is_symmetric: true +is_transitive: true +is_a: RO:0002320 ! evolutionarily related to + +[Typedef] +id: RO:0002159 +name: serially_homologous_to +is_symmetric: true +is_transitive: true +is_a: RO:0002320 ! evolutionarily related to + +[Typedef] +id: RO:0002160 +name: only_in_taxon +def: "x only in taxon y if and only if x is in taxon y, and there is no other organism z such that y!=z a and x is in taxon z." [] +is_a: RO:0002162 ! in taxon + +[Typedef] +id: RO:0002162 +name: in_taxon +def: "x is in taxon y if an only if y is an organism, and the relationship between x and y is one of: part of (reflexive), developmentally preceded by, derives from, secreted by, expressed." [] +holds_over_chain: BFO:0000050 RO:0002162 +holds_over_chain: BFO:0000051 RO:0002162 +holds_over_chain: results_in_developmental_progression_of RO:0002162 +holds_over_chain: RO:0002202 RO:0002162 +holds_over_chain: RO:0002206 RO:0002162 +holds_over_chain: RO:0002214 RO:0002162 +holds_over_chain: RO:0002215 RO:0002162 +holds_over_chain: RO:0002217 RO:0002162 +holds_over_chain: RO:0002225 RO:0002162 +holds_over_chain: RO:0002254 RO:0002162 +is_a: RO:0002320 ! evolutionarily related to + +[Typedef] +id: RO:0002163 +name: spatially_disjoint_from +def: "A is spatially_disjoint_from B if and only if they have no parts in common" [] +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002170 +name: connected_to +def: "a is connected to b if and only if a and b are discrete structure, and there exists some connecting structure c, such that c connects a and b" [] +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002176 +name: connects +def: "c connects a if and only if there exist some b such that a and b are similar parts of the same system, and c connects b, specifically, c connects a with b. When one structure connects two others it unites some aspect of the function or role they play within the system." [] +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002177 +name: attached_to_part_of +def: "a is attached to part of b if a is attached to b, or a is attached to some p, where p is part of b." [] +holds_over_chain: RO:0002371 BFO:0000050 {http://purl.obolibrary.org/obo/RO_0002582="true"} +is_a: RO:0002323 ! mereotopologically related to +is_a: RO:0002567 ! biomechanically related to + +[Typedef] +id: RO:0002178 +name: supplies +def: "Relation between an arterial structure and another structure, where the arterial structure acts as a conduit channeling fluid, substance or energy." [] +is_a: RO:0002170 ! connected to + +[Typedef] +id: RO:0002179 +name: drains +def: "Relation between an collecting structure and another structure, where the collecting structure acts as a conduit channeling fluid, substance or energy away from the other structure." [] +is_a: RO:0002170 ! connected to + +[Typedef] +id: RO:0002180 +name: has_component +def: "w 'has component' p if w 'has part' p and w is such that it can be directly disassembled into into n parts p, p2, p3, ..., pn, where these parts are of similar type." [] +is_a: BFO:0000051 ! has part + +[Typedef] +id: RO:0002200 +name: has_phenotype +def: "A relationship that holds between a biological entity and a phenotype. Here a phenotype is construed broadly as any kind of quality of an organism part, a collection of these qualities, or a change in quality or qualities (e.g. abnormally increased temperature). The subject of this relationship can be an organism (where the organism has the phenotype, i.e. the qualities inhere in parts of this organism), a genomic entity such as a gene or genotype (if modifications of the gene or the genotype causes the phenotype), or a condition such as a disease (such that if the condition inheres in an organism, then the organism has the phenotype)." [] + +[Typedef] +id: RO:0002201 +name: phenotype_of +is_functional: true +inverse_of: RO:0002200 ! has phenotype + +[Typedef] +id: RO:0002202 +name: develops_from +def: "x develops from y if and only if either (a) x directly develops from y or (b) there exists some z such that x directly develops from z and z develops from y" [] +is_transitive: true +is_a: RO:0002258 ! developmentally preceded by + +[Typedef] +id: RO:0002203 +name: develops_into +is_transitive: true +is_a: RO:0002286 ! developmentally succeeded by +is_a: RO:0002387 ! has potential to develop into +is_a: RO:0002388 ! has potential to directly develop into +inverse_of: RO:0002202 ! develops from + +[Typedef] +id: RO:0002204 +name: gene_product_of +def: "definition \"x has gene product of y if and only if y is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from x\"" [] +holds_over_chain: RO:0002512 RO:0002510 +is_a: RO:0002330 ! genomically related to + +[Typedef] +id: RO:0002205 +name: has_gene_product +def: "x has gene product y if and only if x is a gene (SO:0000704) that participates in some gene expression process (GO:0010467) where the output of that process is either y or something that is ribosomally translated from y" [] +holds_over_chain: RO:0002511 RO:0002513 +is_a: RO:0002330 ! genomically related to +inverse_of: RO:0002204 ! gene product of + +[Typedef] +id: RO:0002206 +name: expressed_in +def: "x expressed in y if and only if there is a gene expression process (GO:0010467) that occurs in y, and one of the following holds: (i) x is a gene, and x is transcribed into a transcript as part of the gene expression process (ii) x is a transcript, and the transcription of x is part of the gene expression process (iii) x is a mature gene product such as a protein, and x was translated or otherwise processes from a transcript that was transcribed as part of this gene expression process" [] +is_a: RO:0002330 ! genomically related to +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002207 +name: directly_develops_from +def: "Candidate definition: x directly_develops from y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p, and a substantial portion of the matter of y comes from x, and the start of x is coincident with or after the end of y" [] +is_a: RO:0002202 ! develops from + +[Typedef] +id: RO:0002210 +name: directly_develops_into +is_a: RO:0002203 ! develops into +inverse_of: RO:0002207 ! directly develops from + +[Typedef] +id: RO:0002211 +name: regulates +def: "x regulates y if and only if the x is the realization of a function to exert an effect on the frequency, rate or extent of y" [] +holds_over_chain: RO:0002230 RO:0002211 +holds_over_chain: RO:0002578 RO:0002578 +is_a: RO:0002418 ! causally upstream of or within +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002212 +name: negatively_regulates +def: "x negatively regulates y if and only if the progression of x reduces the frequency, rate or extent of y" [] +holds_over_chain: RO:0002230 RO:0002212 +is_a: RO:0002211 ! regulates + +[Typedef] +id: RO:0002213 +name: positively_regulates +def: "x positively regulates y if and only if the progression of x increases the frequency, rate or extent of y" [] +holds_over_chain: RO:0002230 RO:0002213 +is_a: RO:0002211 ! regulates + +[Typedef] +id: RO:0002214 +name: has_prototype +def: "x has prototype y if and only if x is an instance of C and y is a prototypical instance of C. For example, every instance of heart, both normal and abnormal is related by the has prototype relation to some instance of a \"canonical\" heart, which participates in blood circulation." [] + +[Typedef] +id: RO:0002215 +name: capable_of +def: "A relation between a material entity (such as a cell) and a process, in which the material entity has the ability to carry out the process. " [] +holds_over_chain: RO:0002214 RO:0002217 +is_a: RO:0002216 ! capable of part of + +[Typedef] +id: RO:0002216 +name: capable_of_part_of +def: "c stands in this relationship to p if and only if there exists some p' such that c is capable_of p', and p' is part_of p." [] +holds_over_chain: RO:0002215 BFO:0000050 {http://purl.obolibrary.org/obo/RO_0002582="true"} +is_a: RO:0002328 ! functionally related to +is_a: RO:0002500 ! causal agent in + +[Typedef] +id: RO:0002217 +name: actively_participates_in +def: "x actively participates in y if and only if x participates in y and x realizes some active role" [] +is_a: RO:0000056 ! participates in +inverse_of: RO:0002218 ! has active participant + +[Typedef] +id: RO:0002218 +name: has_active_participant +def: "x has participant y if and only if x realizes some active role that inheres in y" [] +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002219 +name: surrounded_by +def: "x surrounded_by y if and only if (1) x is adjacent to y and for every region r that is adjacent to x, r overlaps y (2) the shared boundary between x and y occupies the majority of the outermost boundary of x" [] +is_a: RO:0002220 ! adjacent to + +[Typedef] +id: RO:0002220 +name: adjacent_to +def: "x adjacent to y if and only if x and y share a boundary" [] +is_a: RO:0002163 ! spatially disjoint from + +[Typedef] +id: RO:0002221 +name: surrounds +is_a: RO:0002220 ! adjacent to +inverse_of: RO:0002219 ! surrounded by + +[Typedef] +id: RO:0002222 +name: temporally_related_to + +[Typedef] +id: RO:0002223 +name: starts +def: "inverse of starts with" [] +is_a: BFO:0000050 ! part of +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: RO:0002224 +name: starts_with +def: "x starts with y if and only if x has part y and the time point at which x starts is equivalent to the time point at which y starts. Formally: α(y) = α(x) ∧ ω(y) < ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] +is_transitive: true +is_a: BFO:0000051 ! has part +is_a: RO:0002222 ! temporally related to +inverse_of: RO:0002223 ! starts + +[Typedef] +id: RO:0002225 +name: develops_from_part_of +def: "x develops from part of y if and only if there exists some z such that x develops from z and z is part of y" [] +holds_over_chain: RO:0002207 BFO:0000050 +is_a: RO:0002202 ! develops from + +[Typedef] +id: RO:0002226 +name: develops_in +def: "x develops_in y if x is located in y whilst x is developing" [] +holds_over_chain: RO:0002207 RO:0001025 +is_a: RO:0002258 ! developmentally preceded by + +[Typedef] +id: RO:0002229 +name: ends +def: "inverse of ends with" [] +is_a: BFO:0000050 ! part of +is_a: RO:0002222 ! temporally related to +inverse_of: RO:0002230 ! ends with + +[Typedef] +id: RO:0002230 +name: ends_with +def: "x ends with y if and only if x has part y and the time point at which x ends is equivalent to the time point at which y ends. Formally: α(y) > α(x) ∧ ω(y) = ω(x), where α is a function that maps a process to a start point, and ω is a function that maps a process to an end point." [] +is_transitive: true +is_a: BFO:0000051 ! has part +is_a: RO:0002222 ! temporally related to + +[Typedef] +id: RO:0002231 +name: has_start_location +def: "x 'has starts location' y if and only if there exists some process z such that x 'starts with' z and z 'occurs in' y" [] +holds_over_chain: RO:0002224 BFO:0000066 +is_a: RO:0002479 ! has part that occurs in + +[Typedef] +id: RO:0002232 +name: has_end_location +def: "x 'has end location' y if and only if there exists some process z such that x 'ends with' z and z 'occurs in' y" [] +holds_over_chain: RO:0002230 BFO:0000066 +is_a: RO:0002479 ! has part that occurs in + +[Typedef] +id: RO:0002233 +name: has_input +def: "p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p." [] +holds_over_chain: RO:0002224 RO:0002233 +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002234 +name: has_output +def: "p has output c iff c is a participant in p, c is present at the end of p, and c is not present at the beginning of p." [] +holds_over_chain: RO:0002230 RO:0002234 +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002254 +name: has_developmental_contribution_from +def: "x has developmental contribution from y iff x has some part z such that z develops from y" [] +holds_over_chain: BFO:0000051 RO:0002202 +is_a: RO:0002258 ! developmentally preceded by + +[Typedef] +id: RO:0002255 +name: developmentally_contributes_to +holds_over_chain: RO:0002203 BFO:0000050 +is_a: RO:0002286 ! developmentally succeeded by +is_a: RO:0002385 ! has potential to developmentally contribute to +inverse_of: RO:0002254 ! has developmental contribution from + +[Typedef] +id: RO:0002256 +name: developmentally_induced_by +def: "t1 induced_by t2 if there is a process of developmental induction (GO:0031128) with t1 and t2 as interacting participants. t2 causes t1 to change its fate from a precursor anatomical structure type T to T', where T' develops_from T" [] +is_a: RO:0002258 ! developmentally preceded by + +[Typedef] +id: RO:0002257 +name: developmentally_induces +def: "Inverse of developmentally induced by" [] +is_a: RO:0002286 ! developmentally succeeded by +is_a: RO:0002386 ! has potential to developmentally induce +inverse_of: RO:0002256 ! developmentally induced by + +[Typedef] +id: RO:0002258 +name: developmentally_preceded_by +def: "Candidate definition: x developmentally related to y if and only if there exists some developmental process (GO:0032502) p such that x and y both participates in p, and x is the output of p and y is the input of p" [] +is_a: RO:0002324 ! developmentally related to + +[Typedef] +id: RO:0002285 +name: developmentally_replaces +def: "x developmentally replaces y if and only if there is some developmental process that causes x to move or to cease to exist, and for the site that was occupied by x to become occupied by y, where y either comes into existence in this site or moves to this site from somewhere else" [] +is_a: RO:0002258 ! developmentally preceded by + +[Typedef] +id: RO:0002286 +name: developmentally_succeeded_by +def: "Inverse of developmentally preceded by" [] +is_a: RO:0002384 ! has developmental potential involving +inverse_of: RO:0002258 ! developmentally preceded by + +[Typedef] +id: RO:0002287 +name: part_of_developmental_precursor_of +holds_over_chain: BFO:0000050 RO:0002210 +is_a: RO:0002286 ! developmentally succeeded by + +[Typedef] +id: RO:0002291 +name: ubiquitously_expressed_in +def: "x is ubiquitously expressed in y if and only if x is expressed in y, and the majority of cells in y express x" [] +is_a: RO:0002206 ! expressed in + +[Typedef] +id: RO:0002292 +name: expresses +def: "Inverse of 'expressed in'" [] +is_a: RO:0002330 ! genomically related to +inverse_of: RO:0002206 ! expressed in + +[Typedef] +id: RO:0002293 +name: ubiquitously_expresses +def: "inverse of ubiquiotously expressed in" [] +is_a: RO:0002292 ! expresses +inverse_of: RO:0002291 ! ubiquitously expressed in + +[Typedef] +id: RO:0002301 +name: results_in_developmental_regression_of +is_a: RO:0002552 ! results in ending of + +[Typedef] +id: RO:0002303 +name: has_habitat +def: "x 'has habitat' y if and only if: x is an organism, y is a habitat, and x is specially adapted (either naturally or via artifical selection) to living in y. Here 'living in' encompasses the majority of the animal's lifespan." [] +is_a: RO:0002321 ! ecologically related to + +[Typedef] +id: RO:0002312 +name: evolutionary_variant_of +is_a: RO:0002320 ! evolutionarily related to + +[Typedef] +id: RO:0002313 +name: transports_or_maintains_localization_of +def: "Holds between p and c when p is a transportation or localization process and the outcome of this process is to regulate the location of c" [] +is_a: RO:0000057 ! has participant +is_a: RO:0002337 ! related via localization to +transitive_over: BFO:0000051 ! has part + +[Typedef] +id: RO:0002314 +name: inheres_in_part_of +def: "q inheres in part of w if and only if there exists some p such that q inheres in p and p part of w." [] +holds_over_chain: RO:0000052 BFO:0000050 {http://purl.obolibrary.org/obo/RO_0002582="true"} +is_a: RO:0002502 ! depends on +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002320 +name: evolutionarily_related_to +def: "A relationship that holds via some environmental process" [] + +[Typedef] +id: RO:0002321 +name: ecologically_related_to +def: "A relationship that is mediated in some way by the environment or environmental feature (ENVO:00002297)" [] + +[Typedef] +id: RO:0002322 +name: confers_advantage_in +is_a: RO:0002321 ! ecologically related to + +[Typedef] +id: RO:0002323 +name: mereotopologically_related_to +def: "A mereological relationship or a topological relationship" [] + +[Typedef] +id: RO:0002324 +name: developmentally_related_to +def: "A relationship that holds between entities participating in some developmental process (GO:0032502)" [] + +[Typedef] +id: RO:0002325 +name: colocalizes_with +def: "a colocalizes_with b if and only if a is transiently or peripherally associated with b[GO]." [] +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002326 +name: contributes_to +is_a: RO:0002216 ! capable of part of +is_a: RO:0002329 ! part of structure that is capable of + +[Typedef] +id: RO:0002327 +name: enables_{http://purl.org/dc/elements/1.1/contributor="http://www.arabidopsis.org/"} +is_a: RO:0002215 ! capable of + +[Typedef] +id: RO:0002328 +name: functionally_related_to + +[Typedef] +id: RO:0002329 +name: part_of_structure_that_is_capable_of +def: "this relation holds between c and p when c is part of some c', and c' is capable of p." [] +holds_over_chain: BFO:0000050 RO:0002215 {http://purl.obolibrary.org/obo/RO_0002581="true"} +is_a: RO:0002328 ! functionally related to + +[Typedef] +id: RO:0002330 +name: genomically_related_to +def: "holds between two entities when some genome-level process such as gene expression is involved. This includes transcriptional, spliceosomal events. These relations can be used between either macromolecule entities (such as regions of nucleic acid) or between their abstract informational counterparts." [] + +[Typedef] +id: RO:0002331 +name: involved_in +def: "c involved_in p if and only if c enables some process p', and p' is part of p" [] +holds_over_chain: RO:0002327 BFO:0000050 +is_a: RO:0002431 ! involved in or regulates +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002332 +name: regulates_levels_of +def: "p regulates levels of c if p regulates some amount (PATO:0000070) of c" [] +is_a: RO:0002328 ! functionally related to + +[Typedef] +id: RO:0002333 +name: enabled_by +def: "inverse of enables" [] +is_a: RO:0002328 ! functionally related to +inverse_of: RO:0002327 ! enables + +[Typedef] +id: RO:0002334 +name: regulated_by +def: "inverse of regulates" [] +is_a: RO:0002427 ! causally downstream of or within +inverse_of: RO:0002211 ! regulates + +[Typedef] +id: RO:0002335 +name: negatively_regulated_by +is_a: RO:0002334 ! regulated by +inverse_of: RO:0002212 ! negatively regulates + +[Typedef] +id: RO:0002336 +name: positively_regulated_by +is_a: RO:0002334 ! regulated by +inverse_of: RO:0002213 ! positively regulates + +[Typedef] +id: RO:0002337 +name: related_via_localization_to +def: "A relationship that holds via some process of localization" [] + +[Typedef] +id: RO:0002338 +name: has_target_start_location +def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from some initial location l to some destination." [] +is_a: RO:0002344 ! results in transport to from or in +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002339 +name: has_target_end_location +def: "This relationship holds between p and l when p is a transport or localization process in which the outcome is to move some cargo c from a an initial location to some destination l." [] +is_a: RO:0002344 ! results in transport to from or in +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002340 +name: imports +def: "Holds between p and c when p is a transportation or localization process and the outcome of this process is to move c to a destination that is part of some s, where the start location of c is part of the region that surrounds s." [] +is_a: RO:0002313 ! transports or maintains localization of +transitive_over: BFO:0000051 ! has part + +[Typedef] +id: RO:0002341 +name: results_in_transport_along +def: "Holds between p and l when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that is aligned_with l " [] +is_a: RO:0002337 ! related via localization to + +[Typedef] +id: RO:0002342 +name: results_in_transport_across +def: "Holds between p and m when p is a transportation or localization process and the outcome of this process is to move c from one location to another, and the route taken by c follows a path that crosses m." [] +is_a: RO:0002344 ! results in transport to from or in + +[Typedef] +id: RO:0002343 +name: results_in_growth_of +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002344 +name: results_in_transport_to_from_or_in +is_a: RO:0002337 ! related via localization to + +[Typedef] +id: RO:0002345 +name: exports +is_a: RO:0002313 ! transports or maintains localization of +transitive_over: BFO:0000051 ! has part + +[Typedef] +id: RO:0002348 +name: results_in_commitment_to +def: "p 'results in commitment to' c if and only if p is a developmental process and c is a cell and p results in the state of c changing such that is can only develop into a single cell type." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of + +[Typedef] +id: RO:0002349 +name: results_in_determination_of +def: "p 'results in determination of' c if and only if p is a developmental process and c is a cell and p results in the state of c changing to be determined. Once a cell becomes determined, it becomes committed to differentiate down a particular pathway regardless of its environment." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of + +[Typedef] +id: RO:0002350 +name: member_of +def: "is member of is a mereological relation between a item and a collection." [] +is_a: BFO:0000050 ! part of +inverse_of: RO:0002351 ! has member + +[Typedef] +id: RO:0002351 +name: has_member +def: "has member is a mereological relation between a collection and an item." [] +is_a: BFO:0000051 ! has part + +[Typedef] +id: RO:0002352 +name: input_of +is_a: RO:0000056 ! participates in +is_a: RO:0002328 ! functionally related to +inverse_of: RO:0002233 ! has input + +[Typedef] +id: RO:0002353 +name: output_of +is_a: RO:0000056 ! participates in +is_a: RO:0002328 ! functionally related to +inverse_of: RO:0002234 ! has output + +[Typedef] +id: RO:0002354 +name: formed_as_result_of +is_a: RO:0002353 ! output of +inverse_of: results_in_formation_of ! results in formation of + +[Typedef] +id: RO:0002355 +name: results_in_structural_organization_of +def: "A relationship between a process and an anatomical entity such that the process contributes to the act of creating the structural organization of the anatomical entity." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002356 +name: results_in_specification_of +def: "The relationship linking a cell and its participation in a process that results in the fate of the cell being specified. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. " [] +is_a: results_in_developmental_progression_of ! results in developmental progression of + +[Typedef] +id: RO:0002357 +name: results_in_developmental_induction_of +def: "p results in developmental induction of c if and only if p is a collection of cell-cell signaling processes that signal to a neighbouring tissue that is the precursor of the mature c, where the signaling results in the commitment to cell types necessary for the formation of c." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of + +[Typedef] +id: RO:0002360 +name: has_dendrite_location +is_a: RO:0002131 ! overlaps + +[Typedef] +id: RO:0002371 +name: attached_to +def: "a is attached to b if and only if a and b are discrete objects or object parts, and there are physical connections between a and b such that a force pulling a will move b, or a force pulling b will move a" [] +is_symmetric: true +is_a: RO:0002170 ! connected to +is_a: RO:0002177 ! attached to part of + +[Typedef] +id: RO:0002372 +name: has_muscle_origin +def: "m has_muscle_origin s iff m is attached_to s, and it is the case that when m contracts, s does not move. The site of the origin tends to be more proximal and have greater mass than what the other end attaches to." [] +is_a: RO:0002371 ! attached to +is_a: RO:0002567 ! biomechanically related to + +[Typedef] +id: RO:0002373 +name: has_muscle_insertion +def: "m has_muscle_insertion s iff m is attaches_to s, and it is the case that when m contracts, s moves. Insertions are usually connections of muscle via tendon to bone." [] +is_a: RO:0002371 ! attached to +is_a: RO:0002567 ! biomechanically related to + +[Typedef] +id: RO:0002374 +name: has_fused_element +def: "x has_fused_element y iff: there exists some z : x has_part z, z homologous_to y, and y is a distinct element, the boundary between x and z is largely fiat" [] +is_a: RO:0002320 ! evolutionarily related to + +[Typedef] +id: RO:0002375 +name: in_branching_relationship_with +is_a: BFO:0000050 ! part of +is_a: RO:0002323 ! mereotopologically related to + +[Typedef] +id: RO:0002376 +name: tributary_of +def: "x tributary_of y if and only if x a channel for the flow of a substance into y, where y is larger than x. If x and y are hydrographic features, then y is the main stem of a river, or a lake or bay, but not the sea or ocean. If x and y are anatomical, then y is a vein." [] +is_a: RO:0002375 ! in branching relationship with + +[Typedef] +id: RO:0002377 +name: distributary_of +def: "x distributary_of y if and only if x is capable of channeling the flow of a substance to y, where y channels less of the substance than x" [] +is_a: RO:0002375 ! in branching relationship with + +[Typedef] +id: RO:0002378 +name: anabranch_of +def: "x anabranch_of y if x is a distributary of y (i.e. it channels a from a larger flow from y) and x ultimately channels the flow back into y." [] +is_a: RO:0002377 ! distributary of +disjoint_from: RO:0002382 ! proper distributary of +disjoint_from: RO:0002383 ! proper tributary of + +[Typedef] +id: RO:0002379 +name: spatially_coextensive_with +def: "x spatially_coextensive_with y if and inly if x and y have the same location" [] +is_a: RO:0002131 ! overlaps + +[Typedef] +id: RO:0002380 +name: branching_part_of +def: "x is a branching part of y if and only if x is part of y and x is connected directly or indirectly to the main stem of y" [] +holds_over_chain: RO:0002377 RO:0002381 +is_a: BFO:0000050 ! part of +is_a: RO:0002375 ! in branching relationship with + +[Typedef] +id: RO:0002381 +name: main_stem_of +def: "x main_stem_of y if y is a branching structure and x is a channel that traces a linear path through y, such that x has higher capacity than any other such path." [] +is_a: RO:0002375 ! in branching relationship with + +[Typedef] +id: RO:0002382 +name: proper_distributary_of +def: "x proper_distributary_of y iff x distributary_of y and x does not flow back into y" [] +is_a: RO:0002377 ! distributary of + +[Typedef] +id: RO:0002383 +name: proper_tributary_of +def: "x proper_tributary_of y iff x tributary_of y and x does not originate from y" [] +is_a: RO:0002376 ! tributary of + +[Typedef] +id: RO:0002384 +name: has_developmental_potential_involving +def: "x has developmental potential involving y iff x is capable of a developmental process with output y. y may be the successor of x, or may be a different structure in the vicinity (as for example in the case of developmental induction)." [] +is_a: RO:0002324 ! developmentally related to + +[Typedef] +id: RO:0002385 +name: has_potential_to_developmentally_contribute_to +def: "x has potential to developmentrally contribute to y iff x developmentally contributes to y or x is capable of developmentally contributing to y" [] +is_a: RO:0002384 ! has developmental potential involving + +[Typedef] +id: RO:0002386 +name: has_potential_to_developmentally_induce +def: "x has potential to developmentally induce y iff x developmentally induces y or x is capable of developmentally inducing y" [] +is_a: RO:0002384 ! has developmental potential involving + +[Typedef] +id: RO:0002387 +name: has_potential_to_develop_into +def: "x has the potential to develop into y iff x develops into y or if x is capable of developing into y" [] +is_a: RO:0002384 ! has developmental potential involving + +[Typedef] +id: RO:0002388 +name: has_potential_to_directly_develop_into +def: "x has potential to directly develop into y iff x directly develops into y or x is capable of directly developing into y" [] +is_a: RO:0002387 ! has potential to develop into + +[Typedef] +id: RO:0002400 +name: has_direct_input +def: "p has direct input c iff c is a participant in p, c is present at the start of p, and the state of c is modified during p." [] +holds_over_chain: RO:0002224 RO:0002400 +is_a: RO:0002233 ! has input + +[Typedef] +id: RO:0002401 +name: obsolete_has_indirect_input +is_obsolete: true + +[Typedef] +id: RO:0002402 +name: obsolete_has_direct_output +def: "p has direct input c iff c is a participanti n p, c is present at the end of p, and c is not present at the beginning of c. " [] +is_obsolete: true + +[Typedef] +id: RO:0002403 +name: obsolete_has_indirect_output +holds_over_chain: RO:0002411 RO:0002402 +is_a: RO:0002234 ! has output +is_obsolete: true + +[Typedef] +id: RO:0002404 +name: causally_downstream_of +def: "inverse of upstream of" [] +is_a: BFO:0000062 ! preceded by +is_a: RO:0002427 ! causally downstream of or within +inverse_of: RO:0002411 ! causally upstream of + +[Typedef] +id: RO:0002405 +name: immediately_causally_downstream_of +is_a: RO:0002087 ! immediately preceded by +is_a: RO:0002404 ! causally downstream of +inverse_of: RO:0002412 ! immediately causally upstream of + +[Typedef] +id: RO:0002406 +name: directly_activates +def: "p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q" [] +is_a: RO:0002213 ! positively regulates +is_a: RO:0002412 ! immediately causally upstream of +is_a: RO:0002578 ! directly regulates + +[Typedef] +id: RO:0002407 +name: indirectly_activates +def: "p directly activates q if and only if p is immediately upstream of q and p is the realization of a function to increase the rate or activity of q" [] +holds_over_chain: RO:0002406 RO:0002406 +holds_over_chain: RO:0002406 RO:0002407 +is_transitive: true +is_a: RO:0002213 ! positively regulates +transitive_over: RO:0002406 ! directly activates + +[Typedef] +id: RO:0002408 +name: directly_inhibits +is_a: RO:0002212 ! negatively regulates +is_a: RO:0002412 ! immediately causally upstream of +is_a: RO:0002578 ! directly regulates + +[Typedef] +id: RO:0002409 +name: indirectly_inhibits +holds_over_chain: RO:0002408 RO:0002408 +holds_over_chain: RO:0002408 RO:0002409 +is_transitive: true +is_a: RO:0002212 ! negatively regulates +transitive_over: RO:0002408 ! directly inhibits + +[Typedef] +id: RO:0002410 +name: causally_related_to +def: "This relation groups causal relations between material entities and causal relations between processes" [] +is_a: RO:0002609 ! related via dependence to + +[Typedef] +id: RO:0002411 +name: causally_upstream_of +def: "p is causally upstream of q if and only if p precedes q and p and q are linked in a causal chain" [] +is_a: BFO:0000063 ! precedes +is_a: RO:0002418 ! causally upstream of or within + +[Typedef] +id: RO:0002412 +name: immediately_causally_upstream_of +def: "p is immediately causally upstream of q iff both (a) p immediately precedes q and (b) p is causally upstream of q. In addition, the output of p must be an input of q." [] +is_a: RO:0002090 ! immediately precedes +is_a: RO:0002411 ! causally upstream of + +[Typedef] +id: RO:0002413 +name: directly_provides_input_for +def: "p1 directly provides input for p2 iff there exists some c such that p1 has_output c and p2 has_input c" [] +holds_over_chain: RO:0002402 RO:0002400 +is_a: RO:0002412 ! immediately causally upstream of +is_a: RO:0002414 ! transitively provides input for + +[Typedef] +id: RO:0002414 +name: transitively_provides_input_for +def: "transitive form of directly_provides_input_for" [] +is_transitive: true +is_a: RO:0002411 ! causally upstream of + +[Typedef] +id: RO:0002418 +name: causally_upstream_of_or_within +def: "p 'causally upstream or within' q iff (1) the end of p is before the end of q and (2) the execution of p exerts some causal influence over the outputs of q; i.e. if p was abolished or the outputs of p were to be modified, this would necessarily affect q." [] +is_transitive: true +is_a: RO:0002501 ! causal relation between processes + +[Typedef] +id: RO:0002424 +name: differs_in + +[Typedef] +id: RO:0002425 +name: differs_in_attribute_of +is_a: RO:0002424 ! differs in + +[Typedef] +id: RO:0002426 +name: differs_in_attribute +is_a: RO:0002424 ! differs in + +[Typedef] +id: RO:0002427 +name: causally_downstream_of_or_within +is_transitive: true +is_a: RO:0002501 ! causal relation between processes +inverse_of: RO:0002418 ! causally upstream of or within + +[Typedef] +id: RO:0002428 +name: involved_in_regulation_of +def: "c involved in regulation of p if c is involved in some 'p' and p' regulates some p" [] +holds_over_chain: RO:0002327 RO:0002211 +holds_over_chain: RO:0002331 RO:0002211 +is_a: RO:0002431 ! involved in or regulates + +[Typedef] +id: RO:0002429 +name: involved_in_positive_regulation_of +holds_over_chain: RO:0002327 RO:0002213 +holds_over_chain: RO:0002331 RO:0002213 +is_a: RO:0002428 ! involved in regulation of + +[Typedef] +id: RO:0002430 +name: involved_in_negative_regulation_of +holds_over_chain: RO:0002327 RO:0002212 +holds_over_chain: RO:0002331 RO:0002212 +is_a: RO:0002428 ! involved in regulation of + +[Typedef] +id: RO:0002431 +name: involved_in_or_regulates +def: "c involved in or regulates p if and only if either (i) c is involved in p or (ii) c is involved in regulation of p" [] +is_a: RO:0002328 ! functionally related to +is_a: RO:0002500 ! causal agent in + +[Typedef] +id: RO:0002432 +name: enables_activity_in +def: "c executes activity in d if and only if c enables p and p occurs_in d" [] +holds_over_chain: RO:0002327 BFO:0000066 {http://purl.obolibrary.org/obo/RO_0002581="true"} +is_a: RO:0002328 ! functionally related to + +[Typedef] +id: RO:0002433 +name: contributes_to_morphology_of +def: "p contributes to morphology of w if and only if a change in the morphology of p entails a change in the morphology of w. Examples: every skull contributes to morphology of the head which it is a part of. Counter-example: nuclei do not generally contribute to the morphology of the cell they are part of, as they are buffered by cytoplasm." [] +is_a: RO:0002131 ! overlaps + +[Typedef] +id: RO:0002434 +name: interacts_with +def: "A relationship that holds between two entities in which the processes executed by the two entities are causally connected." [] +is_symmetric: true + +[Typedef] +id: RO:0002435 +name: genetically_interacts_with +is_symmetric: true +is_a: RO:0002434 ! interacts with + +[Typedef] +id: RO:0002436 +name: molecularly_interacts_with +def: "An interaction relationship in which the two partners are molecular entities and are executing molecular processes that are directly causally connected." [] +is_symmetric: true +is_a: RO:0002434 ! interacts with + +[Typedef] +id: RO:0002437 +name: biotically_interacts_with +def: "An interaction relationship in which at least one of the partners is an organism and the other is either an organism or an abiotic entity with which the organism interacts." [] +is_symmetric: true +is_a: RO:0002321 ! ecologically related to +is_a: RO:0002434 ! interacts with + +[Typedef] +id: RO:0002438 +name: trophically_interacts_with +def: "An interaction relationship in which the partners are related via a feeding relationship." [] +is_a: RO:0002574 ! participates in a biotic-biotic interaction with + +[Typedef] +id: RO:0002439 +name: preys_on +def: "An interaction relationship involving a predation process, where the subject consumes all or part of the target" [] +is_a: RO:0002438 ! trophically interacts with + +[Typedef] +id: RO:0002440 +name: symbiotically_interacts_with +def: "A biotic interaction in which the two organisms live together in more or less intimate association." [] +is_symmetric: true +is_a: RO:0002574 ! participates in a biotic-biotic interaction with + +[Typedef] +id: RO:0002441 +name: commensually_interacts_with +def: "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which one benefits and the other is unaffected (GO)." [] +is_a: RO:0002440 ! symbiotically interacts with + +[Typedef] +id: RO:0002442 +name: mutualistically_interacts_with +def: "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which both organisms benefit from each other (GO)." [] +is_a: RO:0002440 ! symbiotically interacts with + +[Typedef] +id: RO:0002443 +name: interacts_with_via_parasite-host_interaction +def: "An interaction relationship between two organisms living together in more or less intimate association in a relationship in which association is disadvantageous or destructive to one of the organisms (GO)." [] +is_a: RO:0002440 ! symbiotically interacts with + +[Typedef] +id: RO:0002444 +name: parasite_of +is_a: RO:0002443 ! interacts with via parasite-host interaction +is_a: RO:0002454 ! has host + +[Typedef] +id: RO:0002445 +name: parasitized_by +is_a: RO:0002443 ! interacts with via parasite-host interaction +is_a: RO:0002453 ! host of +inverse_of: RO:0002444 ! parasite of + +[Typedef] +id: RO:0002446 +name: participates_in_a_abiotic-biotic_interaction_with +def: "A biotic interaction relationship in which one partner is an organism and the other partner is inorganic. For example, the relationship between a sponge and the substrate to which is it anchored." [] +is_a: RO:0002437 ! biotically interacts with + +[Typedef] +id: RO:0002447 +name: phosphorylates +is_a: RO:0002436 ! molecularly interacts with + +[Typedef] +id: RO:0002448 +name: molecularly_controls +def: "Holds between molecular entities a and b when the execution of a activates or inhibits the activity of b" [] +is_a: RO:0002436 ! molecularly interacts with +is_a: RO:0002566 ! causally influences + +[Typedef] +id: RO:0002449 +name: molecularly_decreases_activity_of +def: "Holds between molecules a and b if and only if a executes a process that directly diminishes a process executed by b." [] +is_a: RO:0002448 ! molecularly controls + +[Typedef] +id: RO:0002450 +name: molecularly_increases_activity_of +def: "Holds between molecules a and b if and only if a executes a process that directly activates a process executed by b." [] +is_a: RO:0002448 ! molecularly controls + +[Typedef] +id: RO:0002451 +name: transmitted_by +def: "A relationship that holds between a disease and organism" [] +is_a: RO:0002321 ! ecologically related to + +[Typedef] +id: RO:0002452 +name: has_symptom +def: "A relation that holds between a disease or an organism and a phenotype" [] +is_a: RO:0002200 ! has phenotype + +[Typedef] +id: RO:0002453 +name: host_of +is_a: RO:0002440 ! symbiotically interacts with + +[Typedef] +id: RO:0002454 +name: has_host +is_a: RO:0002440 ! symbiotically interacts with + +[Typedef] +id: RO:0002455 +name: pollinates +is_a: RO:0002442 ! mutualistically interacts with + +[Typedef] +id: RO:0002456 +name: pollinated_by +is_a: RO:0002442 ! mutualistically interacts with +inverse_of: RO:0002455 ! pollinates + +[Typedef] +id: RO:0002457 +name: acquires_nutrients_from +is_a: RO:0002438 ! trophically interacts with + +[Typedef] +id: RO:0002458 +name: preyed_upon_by +is_a: RO:0002438 ! trophically interacts with +inverse_of: RO:0002439 ! preys on + +[Typedef] +id: RO:0002459 +name: is_vector_for +is_a: RO:0002574 ! participates in a biotic-biotic interaction with +inverse_of: RO:0002460 ! has vector + +[Typedef] +id: RO:0002460 +name: has_vector +is_a: RO:0002459 ! is vector for + +[Typedef] +id: RO:0002461 +name: partner_in +is_a: RO:0000056 ! participates in + +[Typedef] +id: RO:0002462 +name: subject_participant_in +is_a: RO:0002461 ! partner in + +[Typedef] +id: RO:0002463 +name: target_participant_in +is_a: RO:0002461 ! partner in + +[Typedef] +id: RO:0002464 +name: helper_property + +[Typedef] +id: RO:0002465 +name: is_symbiosis +is_a: RO:0002563 ! interaction relation helper property + +[Typedef] +id: RO:0002466 +name: is_commensalism +is_a: RO:0002465 ! is symbiosis + +[Typedef] +id: RO:0002467 +name: is_mutualism +is_a: RO:0002465 ! is symbiosis + +[Typedef] +id: RO:0002468 +name: is_parasitism +is_a: RO:0002465 ! is symbiosis + +[Typedef] +id: RO:0002469 +name: provides_nutrients_for +is_a: RO:0002438 ! trophically interacts with +inverse_of: RO:0002457 ! acquires nutrients from + +[Typedef] +id: RO:0002470 +name: eats +is_a: RO:0002438 ! trophically interacts with + +[Typedef] +id: RO:0002471 +name: is_eaten_by +is_a: RO:0002438 ! trophically interacts with + +[Typedef] +id: RO:0002472 +name: is_evidence_for +def: "A relationship between a piece of evidence a and some entity b, where b is an information content entity, material entity or process, and \nthe a supports either the existence of b, or the truth value of b." [] +is_a: RO:0002616 ! related via evidence or inference to + +[Typedef] +id: RO:0002473 +name: composed_primarily_of +def: "x composed_primarily_of y if and only if more than half of the mass of x is made from y or units of the same type as y." [] +is_a: BFO:0000051 ! has part + +[Typedef] +id: RO:0002476 +name: child_nucleus_of +def: "c is a child nucleus of d if and only if c and d are both nuclei and parts of cells c' and d', where c' is derived from d' by mitosis and the genetic material in c is a copy of the generic material in d" [] +is_a: RO:0002258 ! developmentally preceded by + +[Typedef] +id: RO:0002477 +name: child_nucleus_of_in_hermaphrodite +def: "A child nucleus relationship in which the cells are part of a hermaphroditic organism" [] +is_a: RO:0002476 ! child nucleus of + +[Typedef] +id: RO:0002478 +name: child_nucleus_of_in_male +def: "A child nucleus relationship in which the cells are part of a male organism" [] +is_a: RO:0002476 ! child nucleus of + +[Typedef] +id: RO:0002479 +name: has_part_that_occurs_in +def: "p has part that occurs in c if and only if there exists some p1, such that p has_part p1, and p1 occurs in c." [] +holds_over_chain: BFO:0000051 BFO:0000066 {http://purl.obolibrary.org/obo/RO_0002581="true"} + +[Typedef] +id: RO:0002480 +name: ubiquitinates +def: "An interaction relation between x and y in which x catalyzes a reaction in which one or more ubiquitin groups are added to y" [] +is_a: RO:0002436 ! molecularly interacts with + +[Typedef] +id: RO:0002481 +name: is_kinase_activity +is_a: RO:0002564 ! molecular interaction relation helper property + +[Typedef] +id: RO:0002482 +name: is_ubiquitination +is_a: RO:0002564 ! molecular interaction relation helper property + +[Typedef] +id: RO:0002485 +name: receives_input_from +is_a: RO:0002170 ! connected to +inverse_of: RO:0002486 ! sends output to + +[Typedef] +id: RO:0002486 +name: sends_output_to +is_a: RO:0002170 ! connected to + +[Typedef] +id: RO:0002487 +name: relation_between_structure_and_stage + +[Typedef] +id: RO:0002488 +name: existence_starts_during +def: "x existence starts during y if and only if the time point at which x starts is after or equivalent to the time point at which y starts and before or equivalent to the time point at which y ends. Formally: x existence starts during y iff α(x) >= α(y) & α(x) <= ω(y)." [] +holds_over_chain: RO:0002583 BFO:0000050 +is_a: RO:0002490 ! existence overlaps +is_a: RO:0002496 ! existence starts during or after +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002489 +name: existence_starts_with +def: "x starts ends with y if and only if the time point at which x starts is equivalent to the time point at which y starts. Formally: x existence starts with y iff α(x) = α(y)." [] +is_a: RO:0002488 ! existence starts during + +[Typedef] +id: RO:0002490 +name: existence_overlaps +def: "x existence overlaps y if and only if either (a) the start of x is part of y or (b) the end of x is part of y. Formally: x existence starts and ends during y iff (α(x) >= α(y) & α(x) <= ω(y)) OR (ω(x) <= ω(y) & ω(x) >= α(y))" [] +is_a: RO:0002487 ! relation between structure and stage + +[Typedef] +id: RO:0002491 +name: existence_starts_and_ends_during +def: "x existence starts and ends during y if and only if the start of x is part of y and the end of x is part of y. Formally: x existence starts and ends during y iff α(x) >= α(y) & α(x) <= ω(y) & ω(x) <= ω(y) & ω(x) >= α(y)" [] +is_a: RO:0002488 ! existence starts during +is_a: RO:0002492 ! existence ends during + +[Typedef] +id: RO:0002492 +name: existence_ends_during +def: "x existence ends during y if and only if the time point at which x ends is before or equivalent to the time point at which y ends and after or equivalent to the point at which y starts. Formally: x existence ends during y iff ω(x) <= ω(y) and ω(x) >= α(y)." [] +holds_over_chain: RO:0002593 BFO:0000050 +is_a: RO:0002490 ! existence overlaps +is_a: RO:0002497 ! existence ends during or before +transitive_over: BFO:0000050 ! part of + +[Typedef] +id: RO:0002493 +name: existence_ends_with +def: "x existence ends with y if and only if the time point at which x ends is equivalent to the time point at which y ends. Formally: x existence ends with y iff ω(x) = ω(y)." [] +is_a: RO:0002492 ! existence ends during + +[Typedef] +id: RO:0002494 +name: transformation_of +def: "x transformation of y if x is the immediate transformation of y, or is linked to y through a chain of transformation relationships" [] +is_transitive: true +is_a: BFO:0000062 ! preceded by +is_a: RO:0002202 ! develops from + +[Typedef] +id: RO:0002495 +name: immediate_transformation_of +def: "x immediate transformation of y iff x immediately succeeds y temporally at a time boundary t, and all of the matter present in x at t is present in y at t, and all the matter in y at t is present in x at t" [] +is_a: RO:0002087 ! immediately preceded by +is_a: RO:0002207 ! directly develops from +is_a: RO:0002494 ! transformation of + +[Typedef] +id: RO:0002496 +name: existence_starts_during_or_after +def: "x existence starts during or after y if and only if the time point at which x starts is after or equivalent to the time point at which y starts. Formally: x existence starts during or after y iff α (x) >= α (y)." [] +holds_over_chain: BFO:0000050 RO:0002496 +holds_over_chain: RO:0002258 RO:0002496 +is_a: RO:0002487 ! relation between structure and stage +transitive_over: BFO:0000050 ! part of +transitive_over: BFO:0000062 ! preceded by +transitive_over: RO:0002082 ! simultaneous with + +[Typedef] +id: RO:0002497 +name: existence_ends_during_or_before +def: "x existence ends during or before y if and only if the time point at which x ends is before or equivalent to the time point at which y ends." [] +holds_over_chain: BFO:0000050 RO:0002497 +holds_over_chain: RO:0002286 RO:0002497 +is_a: RO:0002487 ! relation between structure and stage +transitive_over: BFO:0000050 ! part of +transitive_over: BFO:0000063 ! precedes +transitive_over: RO:0002082 ! simultaneous with + +[Typedef] +id: RO:0002500 +name: causal_agent_in +def: "A relationship between a material entity and a process where the material entity has some causal role that influences the process" [] +is_a: RO:0002595 ! causal relation between material entity and a process + +[Typedef] +id: RO:0002501 +name: causal_relation_between_processes +def: "p is causally related to q if and only if p or any part of p and q or any part of q are linked by a chain of events where each event pair is one of direct activation or direct inhibition. p may be upstream, downstream, part of or a container of q." [] +is_a: RO:0002410 ! causally related to + +[Typedef] +id: RO:0002502 +name: depends_on + +[Typedef] +id: RO:0002503 +name: towards +def: "q towards e2 if and only if q is a relational quality such that q inheres-in some e, and e != e2 and q is dependent on e2" [] +is_a: RO:0002502 ! depends on + +[Typedef] +id: RO:0002505 +name: has_intermediate +def: "p has intermediate c if and only if p has parts p1, p2 and p1 has output c, and p2 has input c" [] +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002506 +name: causal_relation_between_material_entities +is_a: RO:0002410 ! causally related to + +[Typedef] +id: RO:0002507 +name: determined_by +def: "s determined by f if and only if s is a type of system, and f is a material entity that is part of s, such that f exerts a strong causal influence on the functioning of s, and the removal of f would cause the collapse of s." [] +is_a: BFO:0000050 ! part of +is_a: RO:0002509 ! determined by part of +is_a: RO:0002559 ! causally influenced by + +[Typedef] +id: RO:0002508 +name: determines +is_a: RO:0002566 ! causally influences +inverse_of: RO:0002507 ! determined by + +[Typedef] +id: RO:0002509 +name: determined_by_part_of +def: "s 'determined by part of' w if and only if there exists some f such that (1) s 'determined by' f and (2) f part_of w, or f=w." [] +holds_over_chain: RO:0002507 BFO:0000050 {http://purl.obolibrary.org/obo/RO_0002582="true"} +is_a: RO:0002131 ! overlaps +is_a: RO:0002506 ! causal relation between material entities + +[Typedef] +id: RO:0002510 +name: transcribed_from +def: "x is transcribed from y if and only if x is synthesized from template y" [] +is_a: RO:0002330 ! genomically related to + +[Typedef] +id: RO:0002511 +name: transcribed_to +is_a: RO:0002330 ! genomically related to +inverse_of: RO:0002510 ! transcribed from + +[Typedef] +id: RO:0002512 +name: ribosomal_translation_of +def: "x is the ribosomal translation of y if and only if a ribosome reads x through a series of triplet codon-amino acid adaptor activities (GO:0030533) and produces y" [] +is_a: RO:0002330 ! genomically related to + +[Typedef] +id: RO:0002513 +name: ribosomally_translates_to +def: "inverse of ribosomal translation of" [] +is_a: RO:0002330 ! genomically related to + +[Typedef] +id: RO:0002514 +name: sequentially_related_to +def: "A relation that holds between two entities that have the property of being sequences or having sequences. " [] + +[Typedef] +id: RO:0002515 +name: sequentially_adjacent_to +def: "x is sequentially adjacent to y iff x and y do not overlap and if there are no base units intervening between x and y" [] +is_a: RO:0002527 ! does not overlap sequence of + +[Typedef] +id: RO:0002516 +name: has_start_sequence +def: "x has start sequence y if the start of x is identical to the start of y, and x has y as a subsequence" [] +is_transitive: true +is_a: RO:0002524 ! has subsequence +inverse_of: RO:0002517 ! is start sequence of + +[Typedef] +id: RO:0002517 +name: is_start_sequence_of +def: "inverse of has start sequence" [] +is_transitive: true +is_a: RO:0002525 ! is subsequence of + +[Typedef] +id: RO:0002518 +name: has_end_sequence +def: "x has end sequence y if the end of x is identical to the end of y, and x has y as a subsequence" [] +is_transitive: true +is_a: RO:0002524 ! has subsequence +inverse_of: RO:0002519 ! is end sequence of + +[Typedef] +id: RO:0002519 +name: is_end_sequence_of +def: "inverse of has end sequence" [] +is_transitive: true +is_a: RO:0002525 ! is subsequence of + +[Typedef] +id: RO:0002520 +name: is_consecutive_sequence_of +def: "x is a consecutive sequence of y iff x has subsequence y, and all the parts of x are made of zero or more repetitions of y or sequences as the same type as y." [] +is_a: RO:0002524 ! has subsequence + +[Typedef] +id: RO:0002521 +name: is_sequentially_aligned_with +def: "x is sequentially aligned with if a significant portion bases of x and y correspond in terms of their base type and their relative ordering" [] +is_symmetric: true +is_a: RO:0002514 ! sequentially related to + +[Typedef] +id: RO:0002522 +name: bounds_sequence_of +def: "x bounds the sequence of y iff the upstream-most part of x is upstream of or coincident with the upstream-most part of y, and the downstream-most part of x is downstream of or coincident with the downstream-most part of y" [] +is_transitive: true +is_a: RO:0002514 ! sequentially related to + +[Typedef] +id: RO:0002523 +name: is_bound_by_sequence_of +def: "inverse of bounds sequence of" [] +is_transitive: true +is_a: RO:0002514 ! sequentially related to +inverse_of: RO:0002522 ! bounds sequence of + +[Typedef] +id: RO:0002524 +name: has_subsequence +def: "x has subsequence y iff all of the sequence parts of x are sequence parts of y" [] +is_transitive: true +is_a: BFO:0000051 ! has part +is_a: RO:0002522 ! bounds sequence of +is_a: RO:0002526 ! overlaps sequence of + +[Typedef] +id: RO:0002525 +name: is_subsequence_of +def: "inverse of has subsequence" [] +is_transitive: true +is_a: BFO:0000050 ! part of +is_a: RO:0002523 ! is bound by sequence of +is_a: RO:0002526 ! overlaps sequence of +inverse_of: RO:0002524 ! has subsequence + +[Typedef] +id: RO:0002526 +name: overlaps_sequence_of +def: "x overlaps the sequence of x if and only if x has a subsequence z and z is a subsequence of y." [] +holds_over_chain: RO:0002524 RO:0002525 +is_symmetric: true +is_a: RO:0002131 ! overlaps +is_a: RO:0002514 ! sequentially related to + +[Typedef] +id: RO:0002527 +name: does_not_overlap_sequence_of +def: "x does not overlaps the sequence of x if and only if there is no z such that x has a subsequence z and z is a subsequence of y." [] +is_symmetric: true +is_a: RO:0002514 ! sequentially related to + +[Typedef] +id: RO:0002528 +name: is_upstream_of_sequence_of +def: "inverse of downstream of sequence of" [] +is_transitive: true +is_a: RO:0002527 ! does not overlap sequence of + +[Typedef] +id: RO:0002529 +name: is_downstream_of_sequence_of +def: "x is downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, or (2) x and y are sequence units, and x is either immediately downstream of y, or transitively downstream of y." [] +is_transitive: true +is_a: RO:0002527 ! does not overlap sequence of +inverse_of: RO:0002529 ! is downstream of sequence of + +[Typedef] +id: RO:0002530 +name: is_immediately_downstream_of_sequence_of +def: "x is immediately downstream of the sequence of y iff either (1) x and y have sequence units, and all units of x are downstream of all units of y, and x is sequentially adjacent to y, or (2) x and y are sequence units, in which case the immediately downstream relation is primitive and defined by context: for DNA bases, y would be adjacent and 5' to y" [] +is_a: RO:0002515 ! sequentially adjacent to +is_a: RO:0002529 ! is downstream of sequence of + +[Typedef] +id: RO:0002531 +name: is_immediately_upstream_of_sequence_of +def: "inverse of immediately downstream of" [] +is_a: RO:0002515 ! sequentially adjacent to +is_a: RO:0002528 ! is upstream of sequence of + +[Typedef] +id: RO:0002551 +name: has_skeleton +def: "A relation between a segment or subdivision of an organism and the maximal subdivision of material entities that provides structural support for that segment or subdivision." [] +is_a: BFO:0000051 ! has part + +[Typedef] +id: RO:0002552 +name: results_in_ending_of +def: "p results in the end of s if p results in a change of state in s whereby s either ceases to exist, or s becomes functionally impaired or s has its fate committed such that it is put on a path to be degraded." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002553 +name: hyperparasite_of +def: "x is a hyperparasite of y iff x is a parasite of a parasite of the target organism y" [] +holds_over_chain: RO:0002444 RO:0002444 +is_a: RO:0002454 ! has host + +[Typedef] +id: RO:0002554 +name: hyperparasitized_by +holds_over_chain: RO:0002445 RO:0002445 +is_a: RO:0002453 ! host of +inverse_of: RO:0002553 ! hyperparasite of + +[Typedef] +id: RO:0002555 +name: allelopath_of +is_a: RO:0002574 ! participates in a biotic-biotic interaction with + +[Typedef] +id: RO:0002556 +name: pathogen_of +is_a: RO:0002454 ! has host +inverse_of: RO:0002557 ! has pathogen + +[Typedef] +id: RO:0002557 +name: has_pathogen +is_a: RO:0002453 ! host of + +[Typedef] +id: RO:0002558 +name: has_evidence +is_a: RO:0002616 ! related via evidence or inference to +inverse_of: RO:0002472 ! is evidence for + +[Typedef] +id: RO:0002559 +name: causally_influenced_by +is_a: RO:0002506 ! causal relation between material entities + +[Typedef] +id: RO:0002563 +name: interaction_relation_helper_property +is_a: RO:0002464 ! helper property + +[Typedef] +id: RO:0002564 +name: molecular_interaction_relation_helper_property +is_a: RO:0002563 ! interaction relation helper property + +[Typedef] +id: RO:0002565 +name: results_in_movement_of +def: "Holds between p and c when p is locomotion process and the outcome of this process is the change of location of c" [GOC:mtg_berkeley_2013] +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002566 +name: causally_influences +def: "Holds between materal entities a and b if the activity of a is causally upstream of the activity of b, or causally upstream of a an activity that modifies b" [] +is_a: RO:0002506 ! causal relation between material entities +inverse_of: RO:0002559 ! causally influenced by + +[Typedef] +id: RO:0002567 +name: biomechanically_related_to +def: "A relation that holds between elements of a musculoskeletal system or its analogs." [] +is_a: RO:0002328 ! functionally related to + +[Typedef] +id: RO:0002568 +name: has_muscle_antagonist +def: "m1 has_muscle_antagonist m2 iff m1 has_muscle_insertion s, m2 has_muscle_insection s, m1 acts in opposition to m2, and m2 is responsible for returning the structure to its initial position." [] +is_a: RO:0002567 ! biomechanically related to + +[Typedef] +id: RO:0002569 +name: has_branching_part +is_a: RO:0002375 ! in branching relationship with +inverse_of: RO:0002380 ! branching part of + +[Typedef] +id: RO:0002570 +name: conduit_for +def: "x is a conduit for y iff y overlaps through the lumen_of of x, and y has parts on either side of the lumen of x." [] +is_a: RO:0002131 ! overlaps + +[Typedef] +id: RO:0002571 +name: lumen_of +def: "x lumen_of y iff x is the space or substance that is part of y and does not cross any of the inner membranes or boundaries of y that is maximal with respect to the volume of the convex hull." [] +is_a: BFO:0000050 ! part of + +[Typedef] +id: RO:0002572 +name: luminal_space_of +def: "s is luminal space of x iff s is lumen_of x and s is an immaterial entity" [] +is_a: RO:0002571 ! lumen of + +[Typedef] +id: RO:0002573 +name: has_modifier +def: "A relation that holds between an attribute or a qualifier and another attribute." [] + +[Typedef] +id: RO:0002574 +name: participates_in_a_biotic-biotic_interaction_with +is_a: RO:0002437 ! biotically interacts with + +[Typedef] +id: RO:0002576 +name: skeleton_of +is_a: BFO:0000050 ! part of +inverse_of: RO:0002551 ! has skeleton + +[Typedef] +id: RO:0002578 +name: directly_regulates +def: "p 'directly regulates' q if and only if p and q are processes, and p regulates q, and q directly follows from p" [] +is_a: RO:0002211 ! regulates +is_a: RO:0002412 ! immediately causally upstream of + +[Typedef] +id: RO:0002583 +name: existence_starts_at_point +def: "x existence starts at point y if and only if the time point at which x starts is equivalent to the time point at which y ends." [] +is_a: RO:0002487 ! relation between structure and stage + +[Typedef] +id: RO:0002584 +name: has_part_structure_that_is_capable_of +def: "s 'has part structure that is capable of' p if and only if there exists some part x such that s 'has part' x and x 'capable of' p" [] +holds_over_chain: BFO:0000051 RO:0002215 +is_a: RO:0002328 ! functionally related to +is_a: RO:0002595 ! causal relation between material entity and a process + +[Typedef] +id: RO:0002585 +name: results_in_closure_of +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002586 +name: results_in_breakdown_of +def: "p results in breakdown of c if and only if the execution of p leads to c no longer being present at the end of p" [] +is_a: RO:0002233 ! has input + +[Typedef] +id: RO:0002587 +name: results_in_synthesis_of +is_a: results_in_formation_of ! results in formation of + +[Typedef] +id: RO:0002588 +name: results_in_assembly_of +is_a: results_in_formation_of ! results in formation of +is_a: RO:0002592 ! results in organization of + +[Typedef] +id: RO:0002589 +name: results_in_catabolism_of +def: "p results in catabolism of c if and only if p is a catabolic process, and the execution of p results in c being broken into smaller parts with energy being released." [] +is_a: RO:0002586 ! results in breakdown of + +[Typedef] +id: RO:0002590 +name: results_in_disassembly_of +is_a: RO:0002586 ! results in breakdown of +is_a: RO:0002592 ! results in organization of + +[Typedef] +id: RO:0002591 +name: results_in_remodeling_of +is_a: RO:0002233 ! has input +is_a: RO:0002592 ! results in organization of + +[Typedef] +id: RO:0002592 +name: results_in_organization_of +def: "p results in organization of c iff p results in the assembly, arrangement of constituent parts, or disassembly of c" [] +is_a: RO:0000057 ! has participant + +[Typedef] +id: RO:0002593 +name: existence_ends_at_point +def: "x existence starts at point y if and only if the time point at which x starts is equivalent to the time point at which y ends." [] +is_a: RO:0002487 ! relation between structure and stage + +[Typedef] +id: RO:0002595 +name: causal_relation_between_material_entity_and_a_process +def: "A relationship that holds between a material entity and a process in which causality is involved, with either the material entity or some part of the material entity exerting some influence over the process, or the process influencing some aspect of the material entity." [] +is_a: RO:0002410 ! causally related to + +[Typedef] +id: RO:0002596 +name: capable_of_regulating +def: "Holds between c and p if and only if c is capable of some activity a, and a regulates p." [] +holds_over_chain: RO:0002215 RO:0002211 +is_a: RO:0002500 ! causal agent in + +[Typedef] +id: RO:0002597 +name: capable_of_negatively_regulating +def: "Holds between c and p if and only if c is capable of some activity a, and a negatively regulates p." [] +holds_over_chain: RO:0002215 RO:0002212 +is_a: RO:0002596 ! capable of regulating + +[Typedef] +id: RO:0002598 +name: capable_of_positively_regulating +def: "Holds between c and p if and only if c is capable of some activity a, and a positively regulates p." [] +holds_over_chain: RO:0002215 RO:0002213 +is_a: RO:0002596 ! capable of regulating + +[Typedef] +id: RO:0002599 +name: capable_of_inhibiting_or_preventing_pathological_process +def: "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a inhibits p." [] +is_a: RO:0002597 ! capable of negatively regulating + +[Typedef] +id: RO:0002600 +name: capable_of_upregulating_or_causing_pathological_process +def: "Holds between a material entity c and a pathological process p if and only if c is capable of some activity a, where a negatively regulates p." [] +is_a: RO:0002598 ! capable of positively regulating + +[Typedef] +id: RO:0002606 +name: is_substance_that_treats +def: "c is a substance that treats d if c is a material entity (such as a small molecule or compound) and d is a pathological process, phenotype or disease, and c is capable of some activity that negative regulates or decreases the magnitude of d." [] +is_a: RO:0002599 ! capable of inhibiting or preventing pathological process + +[Typedef] +id: RO:0002607 +name: is_marker_for +def: "c is marker for d iff the presence or occurrence of d is correlated with the presence of occurrence of c, and the observation of c is used to infer the presence or occurrence of d. Note that this does not imply that c and d are in a direct causal relationship, as it may be the case that there is a third entity e that stands in a direct causal relationship with c and d." [] +is_a: RO:0002610 ! correlated with + +[Typedef] +id: RO:0002608 +name: has_causal_agent +def: "Inverse of 'causal agent in'" [] +is_a: RO:0002410 ! causally related to +inverse_of: RO:0002500 ! causal agent in + +[Typedef] +id: RO:0002609 +name: related_via_dependence_to +def: "A relationship that holds between two entities, where the relationship holds based on the presence or absence of statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." [] + +[Typedef] +id: RO:0002610 +name: correlated_with +def: "A relationship that holds between two entities, where the entities exhibit a statistical dependence relationship. The entities may be statistical variables, or they may be other kinds of entities such as diseases, chemical entities or processes." [] +is_a: RO:0002609 ! related via dependence to + +[Typedef] +id: RO:0002614 +name: is_evidence_with_support_from +def: "A relationship between a piece of evidence and an entity that plays a role in supporting that evidence." [] +is_a: RO:0002616 ! related via evidence or inference to + +[Typedef] +id: RO:0002615 +name: has_model +def: "Inverse of is-model-of" [] +inverse_of: RO:0003301 ! is model of + +[Typedef] +id: RO:0002616 +name: related_via_evidence_or_inference_to + +[Typedef] +id: RO:0002618 +name: visits +is_a: RO:0002574 ! participates in a biotic-biotic interaction with + +[Typedef] +id: RO:0002619 +name: visited_by +is_a: RO:0002574 ! participates in a biotic-biotic interaction with +inverse_of: RO:0002618 ! visits + +[Typedef] +id: RO:0002622 +name: visits_flowers_of +is_a: RO:0002618 ! visits + +[Typedef] +id: RO:0002623 +name: has_flowers_visited_by +is_a: RO:0002619 ! visited by +inverse_of: RO:0002622 ! visits flowers of + +[Typedef] +id: RO:0002624 +name: lays_eggs_in +is_a: RO:0002444 ! parasite of +is_a: RO:0002618 ! visits + +[Typedef] +id: RO:0002625 +name: has_eggs_laid_in_by +is_a: RO:0002445 ! parasitized by +is_a: RO:0002619 ! visited by +inverse_of: RO:0002624 ! lays eggs in + +[Typedef] +id: RO:0002626 +name: kills +is_a: RO:0002574 ! participates in a biotic-biotic interaction with + +[Typedef] +id: RO:0002627 +name: is_killed_by +is_a: RO:0002574 ! participates in a biotic-biotic interaction with +inverse_of: RO:0002626 ! kills + +[Typedef] +id: RO:0002629 +name: directly_positively_regulates +def: "p 'directly positively regulates' q if and only if p and q are processes, and p positively regulates q, and q directly follows from p" [] +is_a: RO:0002213 ! positively regulates +is_a: RO:0002578 ! directly regulates + +[Typedef] +id: RO:0002630 +name: directly_negatively_regulates +def: "p 'directly negatively regulates' q if and only if p and q are processes, and p negatively regulates q, and q directly follows from p" [] +is_a: RO:0002212 ! negatively regulates +is_a: RO:0002578 ! directly regulates + +[Typedef] +id: RO:0002632 +name: ectoparasite_of +def: "A sub-relation of parasite-of in which the parasite lives on or in the integumental system of the host" [] +is_a: RO:0002444 ! parasite of + +[Typedef] +id: RO:0002633 +name: has_ectoparasite +is_a: RO:0002445 ! parasitized by +inverse_of: RO:0002632 ! ectoparasite of + +[Typedef] +id: RO:0002634 +name: endoparasite_of +is_a: RO:0002444 ! parasite of +inverse_of: RO:0002635 ! has endoparasite + +[Typedef] +id: RO:0002635 +name: has_endoparasite +is_a: RO:0002445 ! parasitized by + +[Typedef] +id: RO:0002636 +name: mesoparasite_of +def: "A sub-relation of parasite-of in which the parasite is partially an endoparasite and partially an ectoparasite" [] +is_a: RO:0002444 ! parasite of + +[Typedef] +id: RO:0002637 +name: has_mesoparasite +is_a: RO:0002445 ! parasitized by +inverse_of: RO:0002636 ! mesoparasite of + +[Typedef] +id: RO:0002638 +name: intercellular_endoparasite_of +def: "A sub-relation of endoparasite-of in which the parasite inhabits the spaces between host cells." [] +is_a: RO:0002634 ! endoparasite of +inverse_of: RO:0002639 ! has intercellular endoparasite + +[Typedef] +id: RO:0002639 +name: has_intercellular_endoparasite +is_a: RO:0002635 ! has endoparasite + +[Typedef] +id: RO:0002640 +name: intracellular_endoparasite_of +def: "A sub-relation of endoparasite-of in which the parasite inhabits host cells." [] +is_a: RO:0002634 ! endoparasite of +inverse_of: RO:0002641 ! has intracellular endoparasite + +[Typedef] +id: RO:0002641 +name: has_intracellular_endoparasite +is_a: RO:0002635 ! has endoparasite + +[Typedef] +id: RO:0003000 +name: produces +def: "a produces b if some process that occurs_in a has_output b, where a and b are material entities. Examples: hybridoma cell line produces monoclonal antibody reagent; chondroblast produces avascular GAG-rich matrix." [] +inverse_of: RO:0003001 ! produced by + +[Typedef] +id: RO:0003001 +name: produced_by +def: "a produced_by b iff some process that occurs_in b has_output a." [] + +[Typedef] +id: RO:0003002 +name: represses_expression_of +def: "Holds between protein a (a transcription factor) and DNA element b if and only if a diminishes the process of transcription of b." [] +is_a: RO:0002449 ! molecularly decreases activity of + +[Typedef] +id: RO:0003003 +name: increases_expression_of +def: "Holds between protein a (a transcription factor) and DNA element b if and only if a activates the process of transcription of b." [] +is_a: RO:0002450 ! molecularly increases activity of + +[Typedef] +id: RO:0003301 +name: is_model_of +def: "Relation between a research artifact and an entity it is used to study, in virtue of its replicating or approximating features of the studied entity." [] + +[Typedef] +id: RO:0003302 +name: causes_or_contributes_to_condition +def: "A relationship between an entity (a genotype, genetic variation or environment) and a condition (a phenotype or disease) where the entity has some causal or contributing role that influences the condition." [] +is_a: RO:0002410 ! causally related to + +[Typedef] +id: RO:0003303 +name: causes_condition +def: "A relationship between an entity (a genotype, genetic variation or environment) and a condition (a phenotype or disease) where the entity has a causal role for the condition." [] +is_a: RO:0003302 ! causes or contributes to condition + +[Typedef] +id: RO:0003304 +name: contributes_to_condition +def: "A relationship between an entity (a genotype, genetic variation or environment) and a condition (a phenotype or disease) where the entity has some contributing role in the manifestation of the condition." [] +is_a: RO:0003302 ! causes or contributes to condition + +[Typedef] +id: RO:0003305 +name: contributes_to_severity_of_condition +def: "A relationship between an entity (a genotype, genetic variation or environment) and a condition (a phenotype or disease) where the entity influences the severity with which a condition manifests in an individual." [] +is_a: RO:0003304 ! contributes to condition + +[Typedef] +id: RO:0003306 +name: contributes_to_frequency_of_condition +def: "A relationship between an entity (a genotype, genetic variation or environment) and a condition (a phenotype or disease) where the entity influences the frequency of the condition in a population." [] +is_a: RO:0003304 ! contributes to condition + +[Typedef] +id: RO:0003307 +name: is_preventative_for_condition +def: "A relationship between an entity (a genotype, genetic variation or environment) and a condition (a phenotype or disease) where the entity prevents or reduces the severity of a condition." [] +is_a: RO:0002410 ! causally related to + +[Typedef] +id: RO:0003308 +name: correlated_with_condition +def: "A relationship between an entity and a condition (phenotype or disease) with which it exhibits a statistical dependence relationship." [] +is_a: RO:0002610 ! correlated with + +[Typedef] +id: RO:HOM0000000 +name: in_similarity_relationship_with +def: "Relation between biological objects that resemble or are related to each other sufficiently to warrant a comparison." [BGEE:curator, http://purl.obolibrary.org/obo/HOM_0000000] +is_symmetric: true + +[Typedef] +id: RO:HOM0000001 +name: in_homology_relationship_with +def: "Similarity that results from common evolutionary origin." [http://dx.doi.org/10.1002/bies.950180611, http://dx.doi.org/10.1002/jmor.1051730307, http://dx.doi.org/10.1007/BF02814480, http://purl.obolibrary.org/obo/HOM_0000001] +is_symmetric: true +is_a: RO:0002158 ! shares ancestor with +is_a: RO:HOM0000000 ! in similarity relationship with +disjoint_from: RO:HOM0000002 ! in homoplasy relationship with + +[Typedef] +id: RO:HOM0000002 +name: in_homoplasy_relationship_with +def: "Similarity that results from independent evolution." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000002] +is_symmetric: true +is_a: RO:HOM0000000 ! in similarity relationship with + +[Typedef] +id: RO:HOM0000003 +name: in_homocracy_relationship_with +def: "Similarity that is characterized by the organization of anatomical structures through the expression of homologous or identical patterning genes." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1007/s00427-003-0301-4, http://dx.doi.org/10.1186/1742-9994-2-15, http://purl.obolibrary.org/obo/HOM_0000003] +is_symmetric: true +is_a: RO:0002320 ! evolutionarily related to +is_a: RO:HOM0000000 ! in similarity relationship with + +[Typedef] +id: RO:HOM0000004 +name: in_convergence_relationship_with +def: "Homoplasy that involves different underlying mechanisms or structures." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000004] +is_symmetric: true +is_a: RO:HOM0000002 ! in homoplasy relationship with + +[Typedef] +id: RO:HOM0000005 +name: in_parallelism_relationship_with +def: "Homoplasy that involves homologous underlying mechanisms or structures." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000005] +is_symmetric: true +is_a: RO:HOM0000002 ! in homoplasy relationship with + +[Typedef] +id: RO:HOM0000006 +name: in_structural_homology_relationship_with +def: "Homology that is defined by similarity with regard to selected structural parameters." [http://dx.doi.org/10.1016/j.jhevol.2006.11.014, http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000006, ISBN:0123195837] +is_symmetric: true +is_a: RO:HOM0000001 ! in homology relationship with + +[Typedef] +id: RO:HOM0000007 +name: in_historical_homology_relationship_with +def: "Homology that is defined by common descent." [http://dx.doi.org/10.1016/S0169-5347(97)01125-7, http://purl.obolibrary.org/obo/HOM_0000007, ISBN:0123195837] +is_symmetric: true +is_a: RO:HOM0000001 ! in homology relationship with + +[Typedef] +id: RO:HOM0000008 +name: in_biological_homology_relationship_with +def: "Homology that is defined by sharing of a set of developmental constraints, caused by locally acting self-regulatory mechanisms of differentiation, between individualized parts of the phenotype." [http://dx.doi.org/10.1016/S0169-5347(97)01125-7, http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000008] +is_symmetric: true +is_a: RO:HOM0000001 ! in homology relationship with + +[Typedef] +id: RO:HOM0000009 +name: in_reversal_relationship_with +def: "Homoplasy that involves phenotypes similar to those seen in ancestors within the lineage." [http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://purl.obolibrary.org/obo/HOM_0000009] +is_symmetric: true +is_a: RO:HOM0000002 ! in homoplasy relationship with + +[Typedef] +id: RO:HOM0000010 +name: in_syntenic_homology_relationship_with +def: "Structural homology that is detected by similarity in content and organization between chromosomes." [http://purl.obolibrary.org/obo/HOM_0000010, MeSH:Synteny] +is_symmetric: true +is_a: RO:HOM0000006 ! in structural homology relationship with + +[Typedef] +id: RO:HOM0000011 +name: in_paralogy_relationship_with +def: "Historical homology that involves genes that diverged after a duplication event." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000011, http://www.ncbi.nlm.nih.gov/pubmed/5449325] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with +disjoint_from: RO:HOM0000017 ! in orthology relationship with + +[Typedef] +id: RO:HOM0000012 +name: in_syntenic_paralogy_relationship_with +def: "Paralogy that involves sets of syntenic blocks." [DOI:10.1002/1097-010X(20001215)288\:4<345\:\:AID-JEZ7>3.0.CO;2-Y, http://dx.doi.org/10.1186/1471-213X-7-100, http://purl.obolibrary.org/obo/HOM_0000012] +is_symmetric: true +is_a: RO:HOM0000010 ! in syntenic homology relationship with +is_a: RO:HOM0000011 ! in paralogy relationship with + +[Typedef] +id: RO:HOM0000013 +name: in_syntenic_orthology_relationship_with +def: "Syntenic homology that involves chromosomes of different species." [http://dx.doi.org/10.1101/gr.6380007, http://purl.obolibrary.org/obo/HOM_0000013] +is_symmetric: true +is_a: RO:HOM0000010 ! in syntenic homology relationship with + +[Typedef] +id: RO:HOM0000014 +name: in_partial_homology_relationship_with +def: "Structural homology that involves complex structures from which only a fraction of the elements that can be isolated are separately homologous." [http://purl.obolibrary.org/obo/HOM_0000014, ISBN:0123195837, ISBN:978-0471984931] +is_symmetric: true +is_a: RO:HOM0000006 ! in structural homology relationship with + +[Typedef] +id: RO:HOM0000015 +name: in_protein_structural_homology_relationship_with +def: "Structural homology that is detected at the level of the 3D protein structure, but maybe not at the level of the amino acid sequence." [http://dx.doi.org/10.1016/0022-2836(76)90195-9, http://purl.obolibrary.org/obo/HOM_0000015] +is_symmetric: true +is_a: RO:HOM0000006 ! in structural homology relationship with + +[Typedef] +id: RO:HOM0000016 +name: in_non_functional_homology_relationship_with +def: "Structural homology that involves a pseudogenic feature and its functional ancestor." [http://purl.obolibrary.org/obo/HOM_0000016, SO:non_functional_homolog_of] +is_symmetric: true +is_a: RO:HOM0000006 ! in structural homology relationship with +disjoint_from: RO:HOM0000062 ! in equivalogy relationship with + +[Typedef] +id: RO:HOM0000017 +name: in_orthology_relationship_with +def: "Historical homology that involves genes that diverged after a speciation event." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000017, http://www.ncbi.nlm.nih.gov/pubmed/5449325] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000018 +name: in_xenology_relationship_with +def: "Historical homology that is characterized by an interspecies (horizontal) transfer since the common ancestor." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000018] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000019 +name: in_1_to_1_homology_relationship_with +def: "Historical homology that involves two members sharing no other homologs in the lineages considered." [BGEE:curator, http://purl.obolibrary.org/obo/HOM_0000019] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000020 +name: in_1_to_1_orthology_relationship_with +def: "Orthology that involves two genes that did not experience any duplication after the speciation event that created them." [http://dx.doi.org/10.1007/BF02814484, http://purl.obolibrary.org/obo/HOM_0000020, http://www.ensembl.org/info/docs/compara/homology_method.html] +is_symmetric: true +is_a: RO:HOM0000017 ! in orthology relationship with +is_a: RO:HOM0000019 ! in 1 to 1 homology relationship with + +[Typedef] +id: RO:HOM0000022 +name: in_ohnology_relationship_with +def: "Paralogy that results from a whole genome duplication event." [http://dx.doi.org/10.1038/75560, http://purl.obolibrary.org/obo/HOM_0000022] +is_symmetric: true +is_a: RO:HOM0000011 ! in paralogy relationship with + +[Typedef] +id: RO:HOM0000023 +name: in_in-paralogy_relationship_with +def: "Paralogy that results from a lineage-specific duplication subsequent to a given speciation event." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000023] +is_symmetric: true +is_a: RO:HOM0000011 ! in paralogy relationship with +disjoint_from: RO:HOM0000024 ! in out-paralogy relationship with + +[Typedef] +id: RO:HOM0000024 +name: in_out-paralogy_relationship_with +def: "Paralogy that results from a duplication preceding a given speciation event." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000024] +is_symmetric: true +is_a: RO:HOM0000011 ! in paralogy relationship with + +[Typedef] +id: RO:HOM0000025 +name: in_pro-orthology_relationship_with +def: "1:many orthology that involves a gene in species A and one of its ortholog in species B, when duplications more recent than the species split have occurred in species B but not in species A." [http://dx.doi.org/10.1006/scdb.1999.0338, http://dx.doi.org/10.1038/nrg2099, http://purl.obolibrary.org/obo/HOM_0000025] +is_symmetric: true +is_a: RO:HOM0000034 ! in 1 to many orthology relationship with + +[Typedef] +id: RO:HOM0000026 +name: in_semi-orthology_relationship_with +def: "1:many orthology that involves a gene in species A and its ortholog in species B, when duplications more recent than the species split have occurred in species A but not in species B." [http://dx.doi.org/10.1006/scdb.1999.0338, http://dx.doi.org/10.1038/nrg2099, http://purl.obolibrary.org/obo/HOM_0000026] +is_symmetric: true +is_a: RO:HOM0000034 ! in 1 to many orthology relationship with + +[Typedef] +id: RO:HOM0000027 +name: in_serial_homology_relationship_with +def: "Iterative homology that involves structures arranged along the main body axis." [http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000027] +is_symmetric: true +is_a: RO:HOM0000066 ! in iterative homology relationship with + +[Typedef] +id: RO:HOM0000028 +name: in_heterochronous_homology_relationship_with +def: "Biological homology that is characterized by changes, over evolutionary time, in the rate or timing of developmental events of homologous structures." [http://purl.obolibrary.org/obo/HOM_0000028, ISBN:978-0674639416] +is_symmetric: true +is_a: RO:HOM0000008 ! in biological homology relationship with + +[Typedef] +id: RO:HOM0000029 +name: in_paedomorphorsis_relationship_with +def: "Heterochronous homology that is produced by a retention in adults of a species of traits previously seen only in juveniles." [http://en.wikipedia.org/wiki/Pedomorphosis, http://purl.obolibrary.org/obo/HOM_0000029, ISBN:978-0674639416] +is_symmetric: true +is_a: RO:HOM0000028 ! in heterochronous homology relationship with +disjoint_from: RO:HOM0000030 ! in peramorphosis relationship with + +[Typedef] +id: RO:HOM0000030 +name: in_peramorphosis_relationship_with +def: "Heterochronous homology that is produced by a maturation of individuals of a species past adulthood, which take on hitherto unseen traits." [http://en.wikipedia.org/wiki/Peramorphosis, http://purl.obolibrary.org/obo/HOM_0000030] +is_symmetric: true +is_a: RO:HOM0000028 ! in heterochronous homology relationship with + +[Typedef] +id: RO:HOM0000031 +name: in_progenesis_relationship_with +def: "Paedomorphosis that is produced by precocious sexual maturation of an organism still in a morphologically juvenile stage." [http://en.wikipedia.org/wiki/Progenesis, http://purl.obolibrary.org/obo/HOM_0000031, ISBN:978-0674639416] +is_symmetric: true +is_a: RO:HOM0000029 ! in paedomorphorsis relationship with + +[Typedef] +id: RO:HOM0000032 +name: in_neoteny_relationship_with +def: "Paedomorphosis that is produced by a retardation of somatic development." [http://en.wikipedia.org/wiki/Neoteny, http://purl.obolibrary.org/obo/HOM_0000032, ISBN:978-0674639416] +is_symmetric: true +is_a: RO:HOM0000029 ! in paedomorphorsis relationship with + +[Typedef] +id: RO:HOM0000033 +name: in_mimicry_relationship_with +def: "Convergence that results from co-evolution usually involving an evolutionary arms race." [http://purl.obolibrary.org/obo/HOM_0000033, http:\://en.wikipedia.org/wiki/Mimicry] +is_symmetric: true +is_a: RO:HOM0000004 ! in convergence relationship with + +[Typedef] +id: RO:HOM0000034 +name: in_1_to_many_orthology_relationship_with +def: "Orthology that involves two genes when duplications more recent than the species split have occurred in one species but not the other." [http://dx.doi.org/10.1038/415741a, http://purl.obolibrary.org/obo/HOM_0000034, http://www.ensembl.org/info/docs/compara/homology_method.html] +is_symmetric: true +is_a: RO:HOM0000017 ! in orthology relationship with +is_a: RO:HOM0000037 ! in 1 to many homology relationship with + +[Typedef] +id: RO:HOM0000036 +name: in_many_to_many_homology_relationship_with +def: "Historical homology that involves two members of a larger set of homologs." [http://dx.doi.org/10.1093/molbev/msp002, http://purl.obolibrary.org/obo/HOM_0000036] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000037 +name: in_1_to_many_homology_relationship_with +def: "Historical homology that involves a structure that has no other homologs in the species in which it is defined, and several homologous structures in another species." [BGEE:curator, http://purl.obolibrary.org/obo/HOM_0000037] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000042 +name: in_apomorphy_relationship_with +def: "Historical homology that is based on recent shared ancestry, characterizing a monophyletic group." [http://purl.obolibrary.org/obo/HOM_0000042, ISBN:978-0252068140] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with +disjoint_from: RO:HOM0000043 ! in plesiomorphy relationship with + +[Typedef] +id: RO:HOM0000043 +name: in_plesiomorphy_relationship_with +def: "Historical homology that is based on distant shared ancestry." [http://purl.obolibrary.org/obo/HOM_0000043, ISBN:978-0252068140] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000044 +name: in_deep_homology_relationship_with +def: "Homocracy that involves morphologically and phylogenetically disparate structures that are the result of parallel evolution." [http://dx.doi.org/10.1007/BF02814485, http://dx.doi.org/10.1038/nature07891, http://purl.obolibrary.org/obo/HOM_0000044] +is_symmetric: true +is_a: RO:HOM0000003 ! in homocracy relationship with +is_a: RO:HOM0000005 ! in parallelism relationship with + +[Typedef] +id: RO:HOM0000045 +name: in_hemiplasy_relationship_with +def: "Historical homology that is characterized by topological discordance between a gene tree and a species tree attributable to the phylogenetic sorting of genetic polymorphisms across successive nodes in a species tree." [http://dx.doi.org/10.1073/pnas.0807433105, http://purl.obolibrary.org/obo/HOM_0000045] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000046 +name: in_gametology_relationship_with +def: "Historical homology that involves not recombining and subsequently differentiated sex chromosomes." [http://purl.obolibrary.org/obo/HOM_0000046, http://www.ncbi.nlm.nih.gov/pubmed/11110898] +is_symmetric: true +is_a: RO:HOM0000047 ! in chromosomal homology relationship with + +[Typedef] +id: RO:HOM0000047 +name: in_chromosomal_homology_relationship_with +def: "Historical homology that involves the chromosomes able to pair (synapse) during meiosis." [http://purl.obolibrary.org/obo/HOM_0000047, ISBN:0195307615] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000048 +name: in_many_to_many_orthology_relationship_with +def: "Orthology that involves two genes that experienced duplications more recent than the species split that created them." [http://dx.doi.org/10.1038/415741a, http://purl.obolibrary.org/obo/HOM_0000048, http://www.ensembl.org/info/docs/compara/homology_method.html] +is_symmetric: true +is_a: RO:HOM0000017 ! in orthology relationship with +is_a: RO:HOM0000036 ! in many to many homology relationship with + +[Typedef] +id: RO:HOM0000049 +name: in_within-species_paralogy_relationship_with +def: "Paralogy that involves genes from the same species." [http://purl.obolibrary.org/obo/HOM_0000049, http://www.ensembl.org/info/docs/compara/homology_method.html] +is_symmetric: true +is_a: RO:HOM0000011 ! in paralogy relationship with +disjoint_from: RO:HOM0000050 ! in between-species paralogy relationship with + +[Typedef] +id: RO:HOM0000050 +name: in_between-species_paralogy_relationship_with +def: "Paralogy that involves genes from different species." [http://purl.obolibrary.org/obo/HOM_0000050, http://www.ensembl.org/info/docs/compara/homology_method.html] +is_symmetric: true +is_a: RO:HOM0000011 ! in paralogy relationship with + +[Typedef] +id: RO:HOM0000051 +name: in_postdisplacement_relationship_with +def: "Paedomorphosis that is produced by delayed growth of immature structures into the adult form." [http://en.wikipedia.org/wiki/Pedomorphosis, http://purl.obolibrary.org/obo/HOM_0000051] +is_symmetric: true +is_a: RO:HOM0000029 ! in paedomorphorsis relationship with + +[Typedef] +id: RO:HOM0000052 +name: in_hypermorphosis_relationship_with +def: "Peramorphosis that is produced by a delay in the offset of development." [http://en.wikipedia.org/wiki/Peramorphosis, http://purl.obolibrary.org/obo/HOM_0000052, ISBN:978-0674639416] +is_symmetric: true +is_a: RO:HOM0000030 ! in peramorphosis relationship with + +[Typedef] +id: RO:HOM0000053 +name: in_synology_relationship_with +def: "Xenology that results, not from the transfer of a gene between two species, but from a hybridization of two species." [http://dx.doi.org/10.1007/BF00173425, http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://purl.obolibrary.org/obo/HOM_0000053] +is_symmetric: true +is_a: RO:HOM0000018 ! in xenology relationship with + +[Typedef] +id: RO:HOM0000054 +name: in_isoorthology_relationship_with +def: "Orthology that involves functional equivalent genes with retention of the ancestral function." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://purl.obolibrary.org/obo/HOM_0000054] +is_symmetric: true +is_a: RO:HOM0000017 ! in orthology relationship with +is_a: RO:HOM0000062 ! in equivalogy relationship with + +[Typedef] +id: RO:HOM0000055 +name: in_tandem_paralogy_relationship_with +def: "Paralogy that is characterized by duplication of adjacent sequences on a chromosome segment." [http://dx.doi.org/10.1016/S0168-9525(00)02005-9, http://purl.obolibrary.org/obo/HOM_0000055, ISBN:978-0878932665] +is_symmetric: true +is_a: RO:HOM0000011 ! in paralogy relationship with + +[Typedef] +id: RO:HOM0000057 +name: in_latent_homology_relationship_with +def: "Parallelism that involves morphologically very similar structures, occurring only within some members of a taxon and absent in the common ancestor (which possessed the developmental basis to develop this character)." [http://dx.doi.org/10.1007/BF02814485, http://dx.doi.org/10.1016/j.jhevol.2006.11.010, http://dx.doi.org/10.1186/1742-9994-2-15, http://purl.obolibrary.org/obo/HOM_0000057, ISBN:0199141118] +is_symmetric: true +is_a: RO:HOM0000005 ! in parallelism relationship with +is_a: RO:HOM0000058 ! in syngeny relationship with + +[Typedef] +id: RO:HOM0000058 +name: in_syngeny_relationship_with +def: "Homocracy that involves recognizably corresponding characters that occurs in two or more taxa, or as a repeated unit within an individual." [DOI:10.1002/1521-1878(200009)22\:9<846\:\:AID-BIES10>3.0.CO;2-R, http://dx.doi.org/10.1186/1742-9994-2-15, http://purl.obolibrary.org/obo/HOM_0000058] +is_symmetric: true +is_a: RO:HOM0000003 ! in homocracy relationship with + +[Typedef] +id: RO:HOM0000060 +name: in_apparent_orthology_relationship_with +def: "Between-species paralogy that involves single copy paralogs resulting from reciprocal gene loss." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000060, http://www.ensembl.org/info/docs/compara/homology_method.html] +is_symmetric: true +is_a: RO:HOM0000019 ! in 1 to 1 homology relationship with +is_a: RO:HOM0000050 ! in between-species paralogy relationship with + +[Typedef] +id: RO:HOM0000061 +name: in_pseudoparalogy_relationship_with +def: "Xenology that involves genes that ended up in a given genome as a result of a combination of vertical inheritance and horizontal gene transfer." [http://dx.doi.org/10.1146/annurev.genet.39.073003.114725, http://purl.obolibrary.org/obo/HOM_0000061] +is_symmetric: true +is_a: RO:HOM0000018 ! in xenology relationship with + +[Typedef] +id: RO:HOM0000062 +name: in_equivalogy_relationship_with +def: "Historical homology that involves functional equivalent genes with retention of the ancestral function." [http://dx.doi.org/10.1093/nar/gkl1043, http://purl.obolibrary.org/obo/HOM_0000062] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with +is_a: RO:HOM0000065 ! in functional equivalence relationship with + +[Typedef] +id: RO:HOM0000063 +name: in_interology_relationship_with +def: "Historical homology that involves orthologous pairs of interacting molecules in different organisms." [http://dx.doi.org/10.1101/gr.1774904, http://dx.doi.org/10.1126/science.287.5450.116, http://purl.obolibrary.org/obo/HOM_0000063] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: RO:HOM0000065 +name: in_functional_equivalence_relationship_with +def: "Similarity that is characterized by interchangeability in function." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1038/415741a, http://purl.obolibrary.org/obo/HOM_0000065] +is_symmetric: true +is_a: RO:HOM0000000 ! in similarity relationship with + +[Typedef] +id: RO:HOM0000066 +name: in_iterative_homology_relationship_with +def: "Biological homology that involves parts of the same organism." [http://dx.doi.org/10.1146/annurev.es.20.110189.000411, http://purl.obolibrary.org/obo/HOM_0000066] +is_symmetric: true +is_a: RO:HOM0000008 ! in biological homology relationship with + +[Typedef] +id: RO:HOM0000068 +name: in_paraxenology_relationship_with +def: "Xenology that is characterized by multiple horizontal transfer events, resulting in the presence of two or more copies of the foreign gene in the host genome." [http://purl.obolibrary.org/obo/HOM_0000068, http://www.ncbi.nlm.nih.gov/pubmed/3065587] +is_symmetric: true +is_a: RO:HOM0000018 ! in xenology relationship with + +[Typedef] +id: RO:HOM0000069 +name: in_plerology_relationship_with +def: "Paralogy that is characterized by extra similarity between paralogous sequences resulting from concerted evolution." [http://purl.obolibrary.org/obo/HOM_0000069, http://www.ncbi.nlm.nih.gov/pubmed/3065587] +is_symmetric: true +is_a: RO:HOM0000011 ! in paralogy relationship with + +[Typedef] +id: RO:HOM0000071 +name: in_homotopy_relationship_with +def: "Structural homology that involves structures with the same or similar relative positions." [http://dx.doi.org/10.1007/BF02814484, http://dx.doi.org/10.1007/BF02814485, http://purl.obolibrary.org/obo/HOM_0000071, ISBN:0123195837] +is_symmetric: true +is_a: RO:HOM0000006 ! in structural homology relationship with +disjoint_from: RO:HOM0000072 ! in homeosis relationship with + +[Typedef] +id: RO:HOM0000072 +name: in_homeosis_relationship_with +def: "Biological homology that involves an ectopic structure and the normally positioned structure." [http://dx.doi.org/10.1007/BF02814485, http://dx.doi.org/10.1016/j.cell.2008.06.030, http://purl.obolibrary.org/obo/HOM_0000072] +is_symmetric: true +is_a: RO:HOM0000008 ! in biological homology relationship with + +[Typedef] +id: RO:HOM0000073 +name: in_homoeology_relationship_with +def: "Synology that results from allopolyploidy." [http://dx.doi.org/10.1073/pnas.0505156102, http://purl.obolibrary.org/obo/HOM_0000073] +is_symmetric: true +is_a: RO:HOM0000022 ! in ohnology relationship with +is_a: RO:HOM0000053 ! in synology relationship with + +[Typedef] +id: RO:HOM0000074 +name: in_paramorphism_relationship_with +def: "Iterative homology that involves two structures, one of which originated as a duplicate of the other and co-opted the expression of patterning genes of the ancestral structure." [http://dx.doi.org/10.1007/s10441-007-9023-8, http://dx.doi.org/10.1046/j.1525-142x.2000.00054.x, http://purl.obolibrary.org/obo/HOM_0000074] +is_symmetric: true +is_a: RO:HOM0000003 ! in homocracy relationship with +is_a: RO:HOM0000066 ! in iterative homology relationship with + +[Typedef] +id: RO:HOM0000075 +name: in_regulogy_relationship_with +def: "Historical homology that involves orthologous pairs of transcription factors and downstream regulated genes in different organisms." [http://dx.doi.org/10.1101/gr.1774904, http://purl.obolibrary.org/obo/HOM_0000075] +is_symmetric: true +is_a: RO:HOM0000007 ! in historical homology relationship with + +[Typedef] +id: results_in_acquisition_of_features_of +name: results_in_acquisition_of_features_of +def: "The relationship that links a specified entity with the process that results in an unspecified entity acquiring the features and characteristics of the specified entity" [] +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: results_in_development_of +name: results_in_development_of +def: "p 'results in development of' c if and only if p is a developmental process and p results in the state of c changing from its initial state as a primordium or anlage through its mature state and to its final state." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: results_in_developmental_progression_of +name: results_in_developmental_progression_of +def: "p results in the developmental progression of s iff p is a developmental process and s is an anatomical structure and p causes s to undergo a change in state at some point along its natural developmental cycle (this cycle starts with its formation, through the mature structure, and ends with its loss)." [] +is_a: RO:0002324 ! developmentally related to + +[Typedef] +id: results_in_disappearance_of +name: results_in_disappearance_of +is_a: RO:0002552 ! results in ending of + +[Typedef] +id: results_in_formation_of +name: results_in_formation_of +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0002234 ! has output + +[Typedef] +id: results_in_maturation_of +name: results_in_maturation_of +def: "The relationship that links an entity with a process that results in the progression of the entity over time that is independent of changes in it's shape and results in an end point state of that entity." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: results_in_morphogenesis_of +name: results_in_morphogenesis_of +def: "The relationship that links an entity with the process that results in the formation and shaping of that entity over time from an immature to a mature state." [] +is_a: results_in_developmental_progression_of ! results in developmental progression of +is_a: RO:0000057 ! has participant + +[Typedef] +id: OBO_REL:is_a +name: is_a +comment: This relation is added for backward compatibility with Chado +