diff --git a/expression/integration_test/integration_test.go b/expression/integration_test/integration_test.go
index a43931e417ea0..044743153b780 100644
--- a/expression/integration_test/integration_test.go
+++ b/expression/integration_test/integration_test.go
@@ -7824,7 +7824,7 @@ func TestIfFunctionWithNull(t *testing.T) {
 		testkit.Rows("20000 35100"))
 }
 
-func TestIssue41733(t *testing.T) {
+func TestIssue41733AndIssue45410(t *testing.T) {
 	store := testkit.CreateMockStore(t)
 	tk := testkit.NewTestKit(t, store)
 	tk.MustExec("create database testIssue41733")
@@ -7855,4 +7855,14 @@ func TestIssue41733(t *testing.T) {
 	tk.MustExec("INSERT IGNORE INTO t_big(c0) VALUES (1E20)")
 	tk.MustQuery("show warnings").Check(testkit.Rows("Warning 1264 Out of range value for column 'c0' at row 1"))
 	tk.MustQuery("select * from t_big;").Check(testkit.Rows("18446744073709551615"))
+
+	// Issue 45410
+	tk.MustExec("create database testIssue45410")
+	defer tk.MustExec("drop database testIssue45410")
+	tk.MustExec("use testIssue45410")
+
+	tk.MustExec("DROP TABLE IF EXISTS t1;")
+	tk.MustExec("CREATE TABLE t1 (c1 TINYINT(1) UNSIGNED NOT NULL );")
+	tk.MustExec("INSERT INTO t1 VALUES (0);")
+	tk.MustQuery("SELECT c1>=CAST('-787360724' AS TIME) FROM t1;").Check(testkit.Rows("1"))
 }
diff --git a/types/datum.go b/types/datum.go
index e4978293f79d2..ae752c786e993 100644
--- a/types/datum.go
+++ b/types/datum.go
@@ -1216,9 +1216,10 @@ func (d *Datum) convertToUint(sc *stmtctx.StatementContext, target *FieldType) (
 	case KindMysqlDuration:
 		dec := d.GetMysqlDuration().ToNumber()
 		err = dec.Round(dec, 0, ModeHalfUp)
-		ival, err1 := dec.ToInt()
-		if err1 == nil {
-			val, err = ConvertIntToUint(sc, ival, upperBound, tp)
+		var err1 error
+		val, err1 = ConvertDecimalToUint(sc, dec, upperBound, tp)
+		if err == nil {
+			err = err1
 		}
 	case KindMysqlDecimal:
 		val, err = ConvertDecimalToUint(sc, d.GetMysqlDecimal(), upperBound, tp)