diff --git a/Lib/dataclasses.py b/Lib/dataclasses.py
index 4645ebfa71e71c..18ab69053fd520 100644
--- a/Lib/dataclasses.py
+++ b/Lib/dataclasses.py
@@ -1156,11 +1156,16 @@ def _add_slots(cls, is_frozen, weakref_slot):
         itertools.chain.from_iterable(map(_get_slots, cls.__mro__[1:-1]))
     )
     # The slots for our class.  Remove slots from our base classes.  Add
-    # '__weakref__' if weakref_slot was given.
+    # '__weakref__' if weakref_slot was given, unless it is already present.
     cls_dict["__slots__"] = tuple(
-        itertools.chain(
-            itertools.filterfalse(inherited_slots.__contains__, field_names),
-            ("__weakref__",) if weakref_slot else ())
+        itertools.filterfalse(
+            inherited_slots.__contains__,
+            itertools.chain(
+                # gh-93521: '__weakref__' also needs to be filtered out if
+                # already present in inherited_slots
+                field_names, ('__weakref__',) if weakref_slot else ()
+            )
+        ),
     )
 
     for field_name in field_names:
diff --git a/Lib/test/test_dataclasses.py b/Lib/test/test_dataclasses.py
index 6a36da104ac89a..822e7305bd8a12 100644
--- a/Lib/test/test_dataclasses.py
+++ b/Lib/test/test_dataclasses.py
@@ -3109,6 +3109,54 @@ def test_weakref_slot_make_dataclass(self):
                                     "weakref_slot is True but slots is False"):
             B = make_dataclass('B', [('a', int),], weakref_slot=True)
 
+    def test_weakref_slot_subclass_weakref_slot(self):
+        @dataclass(slots=True, weakref_slot=True)
+        class Base:
+            field: int
+
+        # A *can* also specify weakref_slot=True if it wants to (gh-93521)
+        @dataclass(slots=True, weakref_slot=True)
+        class A(Base):
+            ...
+
+        # __weakref__ is in the base class, not A.  But an instance of A
+        # is still weakref-able.
+        self.assertIn("__weakref__", Base.__slots__)
+        self.assertNotIn("__weakref__", A.__slots__)
+        a = A(1)
+        weakref.ref(a)
+
+    def test_weakref_slot_subclass_no_weakref_slot(self):
+        @dataclass(slots=True, weakref_slot=True)
+        class Base:
+            field: int
+
+        @dataclass(slots=True)
+        class A(Base):
+            ...
+
+        # __weakref__ is in the base class, not A.  Even though A doesn't
+        # specify weakref_slot, it should still be weakref-able.
+        self.assertIn("__weakref__", Base.__slots__)
+        self.assertNotIn("__weakref__", A.__slots__)
+        a = A(1)
+        weakref.ref(a)
+
+    def test_weakref_slot_normal_base_weakref_slot(self):
+        class Base:
+            __slots__ = ('__weakref__',)
+
+        @dataclass(slots=True, weakref_slot=True)
+        class A(Base):
+            field: int
+
+        # __weakref__ is in the base class, not A.  But an instance of
+        # A is still weakref-able.
+        self.assertIn("__weakref__", Base.__slots__)
+        self.assertNotIn("__weakref__", A.__slots__)
+        a = A(1)
+        weakref.ref(a)
+
 
 class TestDescriptors(unittest.TestCase):
     def test_set_name(self):
diff --git a/Misc/NEWS.d/next/Library/2022-06-06-13-19-43.gh-issue-93521._vE8m9.rst b/Misc/NEWS.d/next/Library/2022-06-06-13-19-43.gh-issue-93521._vE8m9.rst
new file mode 100644
index 00000000000000..3a3ff4736d2940
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2022-06-06-13-19-43.gh-issue-93521._vE8m9.rst
@@ -0,0 +1,4 @@
+Fixed a case where dataclasses would try to add ``__weakref__`` into the
+``__slots__`` for a dataclass that specified ``weakref_slot=True`` when it was
+already defined in one of its bases. This resulted in a ``TypeError`` upon the
+new class being created.