diff --git a/graal-nodejs/doc/api/errors.md b/graal-nodejs/doc/api/errors.md
index c589fcd3751..cb10d48f2dd 100644
--- a/graal-nodejs/doc/api/errors.md
+++ b/graal-nodejs/doc/api/errors.md
@@ -1234,6 +1234,23 @@ provided.
 Encoding provided to `TextDecoder()` API was not one of the
 [WHATWG Supported Encodings][].
 
+<a id="ERR_ESM_LOADER_REGISTRATION_UNAVAILABLE"></a>
+
+### `ERR_ESM_LOADER_REGISTRATION_UNAVAILABLE`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+Programmatically registering custom ESM loaders
+currently requires at least one custom loader to have been
+registered via the `--experimental-loader` flag. A no-op
+loader registered via CLI is sufficient
+(for example: `--experimental-loader data:text/javascript,`;
+do not omit the necessary trailing comma).
+A future version of Node.js will support the programmatic
+registration of loaders without needing to also use the flag.
+
 <a id="ERR_EVAL_ESM_CANNOT_PRINT"></a>
 
 ### `ERR_EVAL_ESM_CANNOT_PRINT`
diff --git a/graal-nodejs/doc/api/esm.md b/graal-nodejs/doc/api/esm.md
index ad03dec7ba5..3c32625bda0 100644
--- a/graal-nodejs/doc/api/esm.md
+++ b/graal-nodejs/doc/api/esm.md
@@ -1236,6 +1236,17 @@ console.log('some module!');
 If you run `node --experimental-loader ./import-map-loader.js main.js`
 the output will be `some module!`.
 
+### Register loaders programmatically
+
+<!-- YAML
+added: REPLACEME
+-->
+
+In addition to using the `--experimental-loader` option in the CLI,
+loaders can also be registered programmatically. You can find
+detailed information about this process in the documentation page
+for [`module.register()`][].
+
 ## Resolution and loading algorithm
 
 ### Features
@@ -1632,6 +1643,7 @@ success!
 [`import.meta.url`]: #importmetaurl
 [`import`]: https://developer.mozilla.org/en-US/docs/Web/JavaScript/Reference/Statements/import
 [`module.createRequire()`]: module.md#modulecreaterequirefilename
+[`module.register()`]: module.md#moduleregister
 [`module.syncBuiltinESMExports()`]: module.md#modulesyncbuiltinesmexports
 [`package.json`]: packages.md#nodejs-packagejson-field-definitions
 [`port.ref()`]: https://nodejs.org/dist/latest-v17.x/docs/api/worker_threads.html#portref
diff --git a/graal-nodejs/doc/api/module.md b/graal-nodejs/doc/api/module.md
index cb0b27cb612..2fb1266df48 100644
--- a/graal-nodejs/doc/api/module.md
+++ b/graal-nodejs/doc/api/module.md
@@ -78,6 +78,101 @@ isBuiltin('fs'); // true
 isBuiltin('wss'); // false
 ```
 
+### `module.register()`
+
+<!-- YAML
+added: REPLACEME
+-->
+
+In addition to using the `--experimental-loader` option in the CLI,
+loaders can be registered programmatically using the
+`module.register()` method.
+
+```mjs
+import { register } from 'node:module';
+
+register('http-to-https', import.meta.url);
+
+// Because this is a dynamic `import()`, the `http-to-https` hooks will run
+// before importing `./my-app.mjs`.
+await import('./my-app.mjs');
+```
+
+In the example above, we are registering the `http-to-https` loader,
+but it will only be available for subsequently imported modules—in
+this case, `my-app.mjs`. If the `await import('./my-app.mjs')` had
+instead been a static `import './my-app.mjs'`, _the app would already
+have been loaded_ before the `http-to-https` hooks were
+registered. This is part of the design of ES modules, where static
+imports are evaluated from the leaves of the tree first back to the
+trunk. There can be static imports _within_ `my-app.mjs`, which
+will not be evaluated until `my-app.mjs` is when it's dynamically
+imported.
+
+The `--experimental-loader` flag of the CLI can be used together
+with the `register` function; the loaders registered with the
+function will follow the same evaluation chain of loaders registered
+within the CLI:
+
+```console
+node \
+  --experimental-loader unpkg \
+  --experimental-loader http-to-https \
+  --experimental-loader cache-buster \
+  entrypoint.mjs
+```
+
+```mjs
+// entrypoint.mjs
+import { URL } from 'node:url';
+import { register } from 'node:module';
+
+const loaderURL = new URL('./my-programmatically-loader.mjs', import.meta.url);
+
+register(loaderURL);
+await import('./my-app.mjs');
+```
+
+The `my-programmatic-loader.mjs` can leverage `unpkg`,
+`http-to-https`, and `cache-buster` loaders.
+
+It's also possible to use `register` more than once:
+
+```mjs
+// entrypoint.mjs
+import { URL } from 'node:url';
+import { register } from 'node:module';
+
+register(new URL('./first-loader.mjs', import.meta.url));
+register('./second-loader.mjs', import.meta.url);
+await import('./my-app.mjs');
+```
+
+Both loaders (`first-loader.mjs` and `second-loader.mjs`) can use
+all the resources provided by the loaders registered in the CLI. But
+remember that they will only be available in the next imported
+module (`my-app.mjs`). The evaluation order of the hooks when
+importing `my-app.mjs` and consecutive modules in the example above
+will be:
+
+```console
+resolve: second-loader.mjs
+resolve: first-loader.mjs
+resolve: cache-buster
+resolve: http-to-https
+resolve: unpkg
+load: second-loader.mjs
+load: first-loader.mjs
+load: cache-buster
+load: http-to-https
+load: unpkg
+globalPreload: second-loader.mjs
+globalPreload: first-loader.mjs
+globalPreload: cache-buster
+globalPreload: http-to-https
+globalPreload: unpkg
+```
+
 ### `module.syncBuiltinESMExports()`
 
 <!-- YAML
diff --git a/graal-nodejs/lib/internal/errors.js b/graal-nodejs/lib/internal/errors.js
index 7bc7998f918..d78278c2430 100644
--- a/graal-nodejs/lib/internal/errors.js
+++ b/graal-nodejs/lib/internal/errors.js
@@ -1039,6 +1039,11 @@ E('ERR_ENCODING_INVALID_ENCODED_DATA', function(encoding, ret) {
 }, TypeError);
 E('ERR_ENCODING_NOT_SUPPORTED', 'The "%s" encoding is not supported',
   RangeError);
+E('ERR_ESM_LOADER_REGISTRATION_UNAVAILABLE', 'Programmatically registering custom ESM loaders ' +
+  'currently requires at least one custom loader to have been registered via the --experimental-loader ' +
+  'flag. A no-op loader registered via CLI is sufficient (for example: `--experimental-loader ' +
+  '"data:text/javascript,"` with the necessary trailing comma). A future version of Node.js ' +
+  'will remove this requirement.', Error);
 E('ERR_EVAL_ESM_CANNOT_PRINT', '--print cannot be used with ESM input', Error);
 E('ERR_EVENT_RECURSION', 'The event "%s" is already being dispatched', Error);
 E('ERR_FALSY_VALUE_REJECTION', function(reason) {
diff --git a/graal-nodejs/lib/internal/modules/esm/hooks.js b/graal-nodejs/lib/internal/modules/esm/hooks.js
index 5112ece8452..33d93f741e5 100644
--- a/graal-nodejs/lib/internal/modules/esm/hooks.js
+++ b/graal-nodejs/lib/internal/modules/esm/hooks.js
@@ -44,6 +44,8 @@ const {
   validateString,
 } = require('internal/validators');
 
+const { kEmptyObject } = require('internal/util');
+
 const {
   defaultResolve,
   throwIfInvalidParentURL,
@@ -116,6 +118,23 @@ class Hooks {
   // Cache URLs we've already validated to avoid repeated validation
   #validatedUrls = new SafeSet();
 
+  /**
+   * Import and register custom/user-defined module loader hook(s).
+   * @param {string} urlOrSpecifier
+   * @param {string} parentURL
+   */
+  async register(urlOrSpecifier, parentURL) {
+    const moduleLoader = require('internal/process/esm_loader').esmLoader;
+
+    const keyedExports = await moduleLoader.import(
+      urlOrSpecifier,
+      parentURL,
+      kEmptyObject,
+    );
+
+    this.addCustomLoader(urlOrSpecifier, keyedExports);
+  }
+
   /**
    * Collect custom/user-defined module loader hook(s).
    * After all hooks have been collected, the global preload hook(s) must be initialized.
diff --git a/graal-nodejs/lib/internal/modules/esm/loader.js b/graal-nodejs/lib/internal/modules/esm/loader.js
index 9eb05c020cb..a799d1f2bbc 100644
--- a/graal-nodejs/lib/internal/modules/esm/loader.js
+++ b/graal-nodejs/lib/internal/modules/esm/loader.js
@@ -11,6 +11,7 @@ const {
 } = primordials;
 
 const {
+  ERR_ESM_LOADER_REGISTRATION_UNAVAILABLE,
   ERR_UNKNOWN_MODULE_FORMAT,
 } = require('internal/errors').codes;
 const { getOptionValue } = require('internal/options');
@@ -297,12 +298,19 @@ class CustomizedModuleLoader extends DefaultModuleLoader {
   constructor() {
     super();
 
-    if (hooksProxy) {
-      // The worker proxy is shared across all instances, so don't recreate it if it already exists.
-      return;
-    }
-    const { HooksProxy } = require('internal/modules/esm/hooks');
-    hooksProxy = new HooksProxy(); // The user's custom hooks are loaded within the worker as part of its startup.
+    getHooksProxy();
+  }
+
+  /**
+   * Register some loader specifier.
+   * @param {string} originalSpecifier The specified URL path of the loader to
+   *                                   be registered.
+   * @param {string} parentURL The parent URL from where the loader will be
+   *                           registered if using it package name as specifier
+   * @returns {{ format: string, url: URL['href'] }}
+   */
+  register(originalSpecifier, parentURL) {
+    return hooksProxy.makeSyncRequest('register', originalSpecifier, parentURL);
   }
 
   /**
@@ -380,7 +388,46 @@ function createModuleLoader(useCustomLoadersIfPresent = true) {
   return new DefaultModuleLoader();
 }
 
+/**
+ * Get the HooksProxy instance. If it is not defined, then create a new one.
+ * @returns {HooksProxy}
+ */
+function getHooksProxy() {
+  if (!hooksProxy) {
+    const { HooksProxy } = require('internal/modules/esm/hooks');
+    hooksProxy = new HooksProxy();
+  }
+
+  return hooksProxy;
+}
+
+/**
+ * Register a single loader programmatically.
+ * @param {string} specifier
+ * @param {string} [parentURL]
+ * @returns {void}
+ * @example
+ * ```js
+ * register('./myLoader.js');
+ * register('ts-node/esm', import.meta.url);
+ * register('./myLoader.js', import.meta.url);
+ * register(new URL('./myLoader.js', import.meta.url));
+ * ```
+ */
+function register(specifier, parentURL = 'data:') {
+  // TODO: Remove this limitation in a follow-up before `register` is released publicly
+  if (getOptionValue('--experimental-loader').length < 1) {
+    throw new ERR_ESM_LOADER_REGISTRATION_UNAVAILABLE();
+  }
+
+  const moduleLoader = require('internal/process/esm_loader').esmLoader;
+
+  moduleLoader.register(`${specifier}`, parentURL);
+}
+
 module.exports = {
   DefaultModuleLoader,
   createModuleLoader,
+  getHooksProxy,
+  register,
 };
diff --git a/graal-nodejs/lib/internal/modules/esm/utils.js b/graal-nodejs/lib/internal/modules/esm/utils.js
index 0fd833b6544..4e919cd8330 100644
--- a/graal-nodejs/lib/internal/modules/esm/utils.js
+++ b/graal-nodejs/lib/internal/modules/esm/utils.js
@@ -146,9 +146,9 @@ async function initializeHooks() {
     load(url, context) { return hooks.load(url, context); }
   }
   const privateModuleLoader = new ModuleLoader();
-
   const parentURL = pathToFileURL(cwd).href;
 
+  // TODO(jlenon7): reuse the `Hooks.register()` method for registering loaders.
   for (let i = 0; i < customLoaderURLs.length; i++) {
     const customLoaderURL = customLoaderURLs[i];
 
diff --git a/graal-nodejs/lib/module.js b/graal-nodejs/lib/module.js
index b4a6dd7d18d..ee90e92f530 100644
--- a/graal-nodejs/lib/module.js
+++ b/graal-nodejs/lib/module.js
@@ -2,8 +2,10 @@
 
 const { findSourceMap } = require('internal/source_map/source_map_cache');
 const { Module } = require('internal/modules/cjs/loader');
+const { register } = require('internal/modules/esm/loader');
 const { SourceMap } = require('internal/source_map/source_map');
 
 Module.findSourceMap = findSourceMap;
+Module.register = register;
 Module.SourceMap = SourceMap;
 module.exports = Module;
diff --git a/graal-nodejs/test/es-module/test-esm-loader-hooks.mjs b/graal-nodejs/test/es-module/test-esm-loader-hooks.mjs
index 97f25f2eaa1..afe6f981fd4 100644
--- a/graal-nodejs/test/es-module/test-esm-loader-hooks.mjs
+++ b/graal-nodejs/test/es-module/test-esm-loader-hooks.mjs
@@ -24,6 +24,28 @@ describe('Loader hooks', { concurrency: true }, () => {
     assert.match(lines[3], /{"source":{"type":"Buffer","data":\[.*\]},"format":"json","shortCircuit":true}/);
   });
 
+  it('are called with all expected arguments using register function', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      '--no-warnings',
+      '--experimental-loader=data:text/javascript,',
+      '--input-type=module',
+      '--eval',
+      "import { register } from 'node:module';" +
+      `register(${JSON.stringify(fixtures.fileURL('/es-module-loaders/hooks-input.mjs'))});` +
+      `await import(${JSON.stringify(fixtures.fileURL('/es-modules/json-modules.mjs'))});`,
+    ]);
+
+    assert.strictEqual(stderr, '');
+    assert.strictEqual(code, 0);
+    assert.strictEqual(signal, null);
+
+    const lines = stdout.split('\n');
+    assert.match(lines[0], /{"url":"file:\/\/\/.*\/json-modules\.mjs","format":"test","shortCircuit":true}/);
+    assert.match(lines[1], /{"source":{"type":"Buffer","data":\[.*\]},"format":"module","shortCircuit":true}/);
+    assert.match(lines[2], /{"url":"file:\/\/\/.*\/experimental\.json","format":"test","shortCircuit":true}/);
+    assert.match(lines[3], /{"source":{"type":"Buffer","data":\[.*\]},"format":"json","shortCircuit":true}/);
+  });
+
   describe('should handle never-settling hooks in ESM files', { concurrency: true }, () => {
     it('top-level await of a never-settling resolve', async () => {
       const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
diff --git a/graal-nodejs/test/es-module/test-esm-loader-programmatically.mjs b/graal-nodejs/test/es-module/test-esm-loader-programmatically.mjs
new file mode 100644
index 00000000000..0c20bbcb751
--- /dev/null
+++ b/graal-nodejs/test/es-module/test-esm-loader-programmatically.mjs
@@ -0,0 +1,236 @@
+import { spawnPromisified } from '../common/index.mjs';
+import * as fixtures from '../common/fixtures.js';
+import assert from 'node:assert';
+import { execPath } from 'node:process';
+import { describe, it } from 'node:test';
+
+// This test ensures that the register function can register loaders
+// programmatically.
+
+const commonArgs = [
+  '--no-warnings',
+  '--input-type=module',
+  '--loader=data:text/javascript,',
+];
+
+const commonEvals = {
+  import: (module) => `await import(${JSON.stringify(module)});`,
+  register: (loader, parentURL = 'file:///') => `register(${JSON.stringify(loader)}, ${JSON.stringify(parentURL)});`,
+  dynamicImport: (module) => `await import(${JSON.stringify(`data:text/javascript,${encodeURIComponent(module)}`)});`,
+  staticImport: (module) => `import ${JSON.stringify(`data:text/javascript,${encodeURIComponent(module)}`)};`,
+};
+
+describe('ESM: programmatically register loaders', { concurrency: true }, () => {
+  it('works with only a dummy CLI argument', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--eval',
+      "import { register } from 'node:module';" +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-resolve-passthru.mjs')) +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-load-passthru.mjs')) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stderr, '');
+    assert.strictEqual(code, 0);
+    assert.strictEqual(signal, null);
+
+    const lines = stdout.split('\n');
+
+    assert.match(lines[0], /resolve passthru/);
+    assert.match(lines[1], /load passthru/);
+    assert.match(lines[2], /Hello from dynamic import/);
+
+    assert.strictEqual(lines[3], '');
+  });
+
+  describe('registering via --import', { concurrency: true }, () => {
+    for (const moduleType of ['mjs', 'cjs']) {
+      it(`should programmatically register a loader from a ${moduleType.toUpperCase()} file`, async () => {
+        const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+          ...commonArgs,
+          '--import', fixtures.fileURL('es-module-loaders', `register-loader.${moduleType}`).href,
+          '--eval', commonEvals.staticImport('console.log("entry point")'),
+        ]);
+
+        assert.strictEqual(stderr, '');
+        assert.strictEqual(code, 0);
+        assert.strictEqual(signal, null);
+
+        const [
+          passthruStdout,
+          entryPointStdout,
+        ] = stdout.split('\n');
+
+        assert.match(passthruStdout, /resolve passthru/);
+        assert.match(entryPointStdout, /entry point/);
+      });
+    }
+  });
+
+  it('programmatically registered loaders are appended to an existing chaining', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--loader',
+      fixtures.fileURL('es-module-loaders', 'loader-resolve-passthru.mjs'),
+      '--eval',
+      "import { register } from 'node:module';" +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-load-passthru.mjs')) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stderr, '');
+    assert.strictEqual(code, 0);
+    assert.strictEqual(signal, null);
+
+    const lines = stdout.split('\n');
+
+    assert.match(lines[0], /resolve passthru/);
+    assert.match(lines[1], /resolve passthru/);
+    assert.match(lines[2], /load passthru/);
+    assert.match(lines[3], /Hello from dynamic import/);
+
+    assert.strictEqual(lines[4], '');
+  });
+
+  it('works registering loaders across files', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--eval',
+      commonEvals.import(fixtures.fileURL('es-module-loaders', 'register-programmatically-loader-load.mjs')) +
+      commonEvals.import(fixtures.fileURL('es-module-loaders', 'register-programmatically-loader-resolve.mjs')) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stderr, '');
+    assert.strictEqual(code, 0);
+    assert.strictEqual(signal, null);
+
+    const lines = stdout.split('\n');
+
+    assert.match(lines[0], /resolve passthru/);
+    assert.match(lines[1], /load passthru/);
+    assert.match(lines[2], /Hello from dynamic import/);
+
+    assert.strictEqual(lines[3], '');
+  });
+
+  it('works registering loaders across virtual files', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--eval',
+      commonEvals.import(fixtures.fileURL('es-module-loaders', 'register-programmatically-loader-load.mjs')) +
+      commonEvals.dynamicImport(
+        commonEvals.import(fixtures.fileURL('es-module-loaders', 'register-programmatically-loader-resolve.mjs')) +
+        commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+      ),
+    ]);
+
+    assert.strictEqual(stderr, '');
+    assert.strictEqual(code, 0);
+    assert.strictEqual(signal, null);
+
+    const lines = stdout.split('\n');
+
+    assert.match(lines[0], /resolve passthru/);
+    assert.match(lines[1], /load passthru/);
+    assert.match(lines[2], /Hello from dynamic import/);
+
+    assert.strictEqual(lines[3], '');
+  });
+
+  it('works registering the same loaders more them once', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--eval',
+      "import { register } from 'node:module';" +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-resolve-passthru.mjs')) +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-load-passthru.mjs')) +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-resolve-passthru.mjs')) +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-load-passthru.mjs')) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stderr, '');
+    assert.strictEqual(code, 0);
+    assert.strictEqual(signal, null);
+
+    const lines = stdout.split('\n');
+
+    assert.match(lines[0], /resolve passthru/);
+    assert.match(lines[1], /resolve passthru/);
+    assert.match(lines[2], /load passthru/);
+    assert.match(lines[3], /load passthru/);
+    assert.match(lines[4], /Hello from dynamic import/);
+
+    assert.strictEqual(lines[5], '');
+  });
+
+  it('works registering loaders as package name', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--eval',
+      "import { register } from 'node:module';" +
+      commonEvals.register('resolve', fixtures.fileURL('es-module-loaders', 'package.json')) +
+      commonEvals.register('load', fixtures.fileURL('es-module-loaders', 'package.json')) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stderr, '');
+    assert.strictEqual(code, 0);
+    assert.strictEqual(signal, null);
+
+    const lines = stdout.split('\n');
+
+    assert.match(lines[0], /resolve passthru/);
+    assert.match(lines[1], /load passthru/);
+    assert.match(lines[2], /Hello from dynamic import/);
+
+    assert.strictEqual(lines[3], '');
+  });
+
+  it('does not work without dummy CLI loader', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      '--input-type=module',
+      '--eval',
+      "import { register } from 'node:module';" +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'loader-load-passthru.mjs')) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stdout, '');
+    assert.strictEqual(code, 1);
+    assert.strictEqual(signal, null);
+    assert.match(stderr, /ERR_ESM_LOADER_REGISTRATION_UNAVAILABLE/);
+  });
+
+  it('does not work with a loader specifier that does not exist', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--eval',
+      "import { register } from 'node:module';" +
+      commonEvals.register('./not-found.mjs', import.meta.url) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stdout, '');
+    assert.strictEqual(code, 1);
+    assert.strictEqual(signal, null);
+    assert.match(stderr, /ERR_MODULE_NOT_FOUND/);
+  });
+
+  it('does not work with a loader that got syntax errors', async () => {
+    const { code, signal, stdout, stderr } = await spawnPromisified(execPath, [
+      ...commonArgs,
+      '--eval',
+      "import { register } from 'node:module';" +
+      commonEvals.register(fixtures.fileURL('es-module-loaders', 'syntax-error.mjs')) +
+      commonEvals.dynamicImport('console.log("Hello from dynamic import");'),
+    ]);
+
+    assert.strictEqual(stdout, '');
+    assert.strictEqual(code, 1);
+    assert.strictEqual(signal, null);
+    assert.match(stderr, /SyntaxError/);
+  });
+});
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/hooks-input.mjs b/graal-nodejs/test/fixtures/es-module-loaders/hooks-input.mjs
index 5f61f679515..ee0a468cc0e 100644
--- a/graal-nodejs/test/fixtures/es-module-loaders/hooks-input.mjs
+++ b/graal-nodejs/test/fixtures/es-module-loaders/hooks-input.mjs
@@ -17,7 +17,11 @@ export async function resolve(specifier, context, next) {
   if (resolveCalls === 1) {
     url = new URL(specifier).href;
     assert.match(specifier, /json-modules\.mjs$/);
-    assert.strictEqual(context.parentURL, undefined);
+
+    if (!(/\[eval\d*\]$/).test(context.parentURL)) {
+      assert.strictEqual(context.parentURL, undefined);
+    }
+
     assert.deepStrictEqual(context.importAssertions, {});
   } else if (resolveCalls === 2) {
     url = new URL(specifier, context.parentURL).href;
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/loader-load-passthru.mjs b/graal-nodejs/test/fixtures/es-module-loaders/loader-load-passthru.mjs
index 22fd7b0413a..72ff6b56122 100644
--- a/graal-nodejs/test/fixtures/es-module-loaders/loader-load-passthru.mjs
+++ b/graal-nodejs/test/fixtures/es-module-loaders/loader-load-passthru.mjs
@@ -1,6 +1,5 @@
 import { writeSync } from 'node:fs';
 
-
 export async function load(url, context, next) {
   // This check is needed to make sure that we don't prevent the
   // resolution from follow-up loaders. It wouldn't be a problem
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/loader-resolve-passthru.mjs b/graal-nodejs/test/fixtures/es-module-loaders/loader-resolve-passthru.mjs
index 3a313611eb3..f388f0db273 100644
--- a/graal-nodejs/test/fixtures/es-module-loaders/loader-resolve-passthru.mjs
+++ b/graal-nodejs/test/fixtures/es-module-loaders/loader-resolve-passthru.mjs
@@ -1,6 +1,5 @@
 import { writeSync } from 'node:fs';
 
-
 export async function resolve(specifier, context, next) {
   // This check is needed to make sure that we don't prevent the
   // resolution from follow-up loaders. It wouldn't be a problem
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/node_modules/load/index.mjs b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/load/index.mjs
new file mode 100644
index 00000000000..db98e8d9f87
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/load/index.mjs
@@ -0,0 +1 @@
+export * from '../../loader-load-passthru.mjs'
\ No newline at end of file
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/node_modules/load/package.json b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/load/package.json
new file mode 100644
index 00000000000..b6629e24788
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/load/package.json
@@ -0,0 +1,3 @@
+{
+  "exports": "./index.mjs"
+}
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/node_modules/resolve/index.mjs b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/resolve/index.mjs
new file mode 100644
index 00000000000..b3769d96135
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/resolve/index.mjs
@@ -0,0 +1 @@
+export * from '../../loader-resolve-passthru.mjs'
\ No newline at end of file
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/node_modules/resolve/package.json b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/resolve/package.json
new file mode 100644
index 00000000000..b6629e24788
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/node_modules/resolve/package.json
@@ -0,0 +1,3 @@
+{
+  "exports": "./index.mjs"
+}
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/register-loader.cjs b/graal-nodejs/test/fixtures/es-module-loaders/register-loader.cjs
new file mode 100644
index 00000000000..9e18dfa77e2
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/register-loader.cjs
@@ -0,0 +1,4 @@
+const { register } = require('node:module');
+const fixtures = require('../../common/fixtures.js');
+
+register(fixtures.fileURL('es-module-loaders', 'loader-resolve-passthru.mjs'));
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/register-loader.mjs b/graal-nodejs/test/fixtures/es-module-loaders/register-loader.mjs
new file mode 100644
index 00000000000..f3cb2de8da3
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/register-loader.mjs
@@ -0,0 +1,4 @@
+import { register } from 'node:module';
+import fixtures from '../../common/fixtures.js';
+
+register(fixtures.fileURL('es-module-loaders', 'loader-resolve-passthru.mjs'));
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/register-programmatically-loader-load.mjs b/graal-nodejs/test/fixtures/es-module-loaders/register-programmatically-loader-load.mjs
new file mode 100644
index 00000000000..fe22dc7203e
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/register-programmatically-loader-load.mjs
@@ -0,0 +1,4 @@
+import * as fixtures from '../../common/fixtures.mjs';
+import { register } from 'node:module';
+
+register(fixtures.fileURL('es-module-loaders', 'loader-load-passthru.mjs'));
diff --git a/graal-nodejs/test/fixtures/es-module-loaders/register-programmatically-loader-resolve.mjs b/graal-nodejs/test/fixtures/es-module-loaders/register-programmatically-loader-resolve.mjs
new file mode 100644
index 00000000000..3ae8841da83
--- /dev/null
+++ b/graal-nodejs/test/fixtures/es-module-loaders/register-programmatically-loader-resolve.mjs
@@ -0,0 +1,3 @@
+import { register } from 'node:module';
+
+register('./loader-resolve-passthru.mjs', import.meta.url);