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Revise granule cell hierarchy to add more detail. #2012
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See #1980 for examples of classification based on derivation from upper/lower rhombic lip. |
Edits for 'cerebellar granule cell'
CURRENT: "Granule cell that is part of the cerebellum." PROPOSED: "An excitatory granule cell with a soma located in the granular layer of cerebellar cortex. In an adult, a cerebellar granule cell has short dendrites with a characteristic claw-like appearance and a long axon that ascends to the molecular layer where it bifurcates (except in non-teleost fish, where it does not bifurcate) and extends mediolaterally to form parallel fibers."
REASON: Redundant, already in logical definition.
Related edits for 'granule cell precursor':
CURRENT: 'granule cell precursor' PROPOSED: 'cerebellar granule cell precursor' REASON: The text def and dbxref are specific to cerebellar granule cell precursors.
Related edits for 'parallel fiber': |
Edits for ‘dentate gyrus of hippocampal formation granule cell’
CURRENT: ‘dentate gyrus of hippocampal formation granule cell’ PROPOSED: ‘dentate gyrus granule cell’ (and make original label an exact syn)
CURRENT: "The principal cell type of the dentate gyrus." PROPOSED: “A granule cell that has soma location in the dentate gyrus cell layer of the hippocampal formation and has an elliptical cell body and characteristic cone-shaped tree of spiny apical dendrites. The branches extend throughout the molecular layer and the distal tips of the dendritic tree end just at the hippocampal fissure or at the ventricular surface. The dentate gyrus of hippocampal formation granule cell is the principal cell type of the dentate gyrus.” PMID:17765709
CURRENT: 'granule cell' PROPOSED: ‘hippocampal granule cell'
CURRENT: “The granule cell has a characteristic cone-shaped tree of spiny apical dendrites.” PROPOSED: “As far as can be determined, all dentate granule cells appear to project to CA3 and the axon trajectory is partially correlated with the position of the parent cell body.” Related edits for dentate gyrus granule cell layer (Uberon ticket):
CURRENT: 'composed primarily of' some 'granule cell' Related edits for dentate gyrus mossy fiber (GO ticket):
CURRENT: 'part of' some 'granule cell'
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Looks good but please simplify name: suggest: dentate gyrus granule cell |
Once all axioms are in place please check whether the DL query 'develops from' some 'upper rhombic lip' returns this cell type. |
Added to action items above. Will add current label as an exact syn. |
Looks like it does: |
…le_cell Addresses #2012 edit cerebellar granule cell and precursor
…anule_cell Addresses #2012 Edit 'dentate gyrus of hippocampal formation granule cell'
I wonder if hippocampal granule cell and dentate gyrus granule cell should be exact synonyms. |
Thanks for the suggestion, @raymond91125. |
Edits for 'olfactory granule cell'
CURRENT: "Granule cell that is part of the olfactory bulb." PROPOSED: "A granule cell that has a soma located in an olfactory bulb granule cell layer. An olfactory granule cell is an interneuron that lacks an axon, makes reciprocal dendro-dendritic synapses with mitral cells and tufted cells and is involved in the fine spatio-temporal tuning of the responses of these principal olfactory bulb neurons to odors."
"olfactory bulb granule cell" (exact, doi:10.1038/s41598-018-27692-8)
CURRENT: 'granule cell' and ('has soma location' some 'olfactory bulb') PROPOSED: 'granule cell' and ('has soma location' some 'olfactory bulb granule cell layer')
"Granule cells are the most abundant neuronal population in the olfactory bulb and are continuously renewed throughout life." |
…e_cell Addresses #2012 Edit 'olfactory granule cell'
The general class 'granule cell' now has a definition, but this is necessarily vague given that this is a grouping of likely unrelated neuron types, all of which are small.
This means that 'granule cell' is uninformative as a genus. The logical and textual definitions of types of granule cell should therefore be revised from the very simple genus-type definitions currently present.
e.g.
cerebellar granule cell
http://purl.obolibrary.org/obo/CL_0001031
Granule cell that is part of the cerebellum.
Wikipedia has nice potted descriptions of these. e.g. https://en.wikipedia.org/wiki/Granule_cell#Cerebellar_granule_cell
-> A neuron with a very small soma located in the granule cell layer cerebral cortex. It develops from precursors in the rhombic lip. These cells have several short dendrites which terminate with claw-shaped endings and a single axon that ascends into the molecular layer where it splits to form parallel fibers.
Updates to logical axoms
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